Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis.
Retinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and f...
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2016-10-01
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Online Access: | https://doi.org/10.1371/journal.pbio.1002569 |
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doaj-1c2df663a443406993a9e1c74df52e562021-07-02T17:10:09ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852016-10-011410e100256910.1371/journal.pbio.1002569Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis.E CastaldiG M CicchiniL CinelliL BiagiS RizzoM C MorroneRetinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI). After surgery, six out of seven retinitis pigmentosa (RP) blind subjects were able to detect high-contrast stimuli using the prosthetic implant. However, direction discrimination to contrast modulated stimuli remained at chance level in all of them. No subject showed any improvement of contrast sensitivity in either eye when not using the Argus II. Before the implant, the Blood Oxygenation Level Dependent (BOLD) activity in V1 and the lateral geniculate nucleus (LGN) was very weak or absent. Surprisingly, after prolonged use of Argus II, BOLD responses to visual input were enhanced. This is, to our knowledge, the first study tracking the neural changes of visual areas in patients after retinal implant, revealing a capacity to respond to restored visual input even after years of deprivation.https://doi.org/10.1371/journal.pbio.1002569 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
E Castaldi G M Cicchini L Cinelli L Biagi S Rizzo M C Morrone |
spellingShingle |
E Castaldi G M Cicchini L Cinelli L Biagi S Rizzo M C Morrone Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. PLoS Biology |
author_facet |
E Castaldi G M Cicchini L Cinelli L Biagi S Rizzo M C Morrone |
author_sort |
E Castaldi |
title |
Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. |
title_short |
Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. |
title_full |
Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. |
title_fullStr |
Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. |
title_full_unstemmed |
Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. |
title_sort |
visual bold response in late blind subjects with argus ii retinal prosthesis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2016-10-01 |
description |
Retinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI). After surgery, six out of seven retinitis pigmentosa (RP) blind subjects were able to detect high-contrast stimuli using the prosthetic implant. However, direction discrimination to contrast modulated stimuli remained at chance level in all of them. No subject showed any improvement of contrast sensitivity in either eye when not using the Argus II. Before the implant, the Blood Oxygenation Level Dependent (BOLD) activity in V1 and the lateral geniculate nucleus (LGN) was very weak or absent. Surprisingly, after prolonged use of Argus II, BOLD responses to visual input were enhanced. This is, to our knowledge, the first study tracking the neural changes of visual areas in patients after retinal implant, revealing a capacity to respond to restored visual input even after years of deprivation. |
url |
https://doi.org/10.1371/journal.pbio.1002569 |
work_keys_str_mv |
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