Further development of the baboon as a model for acute schistosomiasis

• Main Authors: Raymond T. Damian, Miguel A. de la Rosa, Daniel J. Murfin, Clarence A. Rawlings, Peter J. Weina, Yang Ping Xue
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1992-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Schistosoma mansoni; experimental model; acute stage; baboon
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800041

Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni.