Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma
Abstract Background Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypothesized that pulmonary outcomes and health-related quality of life (HRQ...
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doaj-1c33d00c8f064bfeaace9058652167102020-11-25T03:05:34ZengBMCRespiratory Research1465-993X2019-05-0120111010.1186/s12931-019-1075-1Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthmaPetra Um-Bergström0Jenny Hallberg1Melvin Pourbazargan2Eva Berggren-Broström3Giovanni Ferrara4Maria J. Eriksson5Sven Nyrén6Jing Gao7Gunnar Lilja8Anders Lindén9Åsa M. Wheelock10Erik Melén11C. Magnus Sköld12Sachs’ Children and Youth Hospital, Department of Pediatrics, SödersjukhusetSachs’ Children and Youth Hospital, Department of Pediatrics, SödersjukhusetDepartment of Respiratory Medicine & Allergy, Karolinska University HospitalSachs’ Children and Youth Hospital, Department of Pediatrics, SödersjukhusetDepartment of Respiratory Medicine & Allergy, Karolinska University HospitalDepartment of Clinical Physiology, Karolinska University HospitalDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Medicine, Karolinska InstitutetSachs’ Children and Youth Hospital, Department of Pediatrics, SödersjukhusetDepartment of Respiratory Medicine & Allergy, Karolinska University HospitalDepartment of Medicine, Karolinska InstitutetSachs’ Children and Youth Hospital, Department of Pediatrics, SödersjukhusetDepartment of Respiratory Medicine & Allergy, Karolinska University HospitalAbstract Background Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypothesized that pulmonary outcomes and health-related quality of life (HRQoL) were different in adults born preterm with and without a history of BPD compared to asthmatics and healthy individuals. Methods We evaluated 96 young adults from the LUNAPRE cohort (clinicaltrials.gov/ct2/show/NCT02923648), including 26 individuals born preterm with a history of BPD (BPD), 23 born preterm without BPD (preterm), 23 asthmatics and 24 healthy controls. Extensive lung function testing and HRQoL were assessed. Results The BPD group had more severe airway obstruction compared to the preterm-, (FEV1− 0.94 vs. 0.28 z-scores; p ≤ 0.001); asthmatic- (0.14 z-scores, p ≤ 0.01) and healthy groups (0.78 z-scores, p ≤ 0.001). Further, they had increased ventilation inhomogeneity compared to the preterm- (LCI 6.97 vs. 6.73, p ≤ 0.05), asthmatic- (6.75, p = 0.05) and healthy groups (6.50 p ≤ 0.001). Both preterm groups had lower DLCO compared to healthy controls (p ≤ 0.001 for both). HRQoL showed less physical but more psychological symptoms in the BPD group compared to asthmatics. Conclusions Lung function impairment and HRQoL in adults with a history of BPD differed from that in asthmatics highlighting the need for objective assessment of lung health.http://link.springer.com/article/10.1186/s12931-019-1075-1Bronchopulmonary dysplasiaAdultsAstmaLung function testsOscillometrySpirometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Petra Um-Bergström Jenny Hallberg Melvin Pourbazargan Eva Berggren-Broström Giovanni Ferrara Maria J. Eriksson Sven Nyrén Jing Gao Gunnar Lilja Anders Lindén Åsa M. Wheelock Erik Melén C. Magnus Sköld |
spellingShingle |
Petra Um-Bergström Jenny Hallberg Melvin Pourbazargan Eva Berggren-Broström Giovanni Ferrara Maria J. Eriksson Sven Nyrén Jing Gao Gunnar Lilja Anders Lindén Åsa M. Wheelock Erik Melén C. Magnus Sköld Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma Respiratory Research Bronchopulmonary dysplasia Adults Astma Lung function tests Oscillometry Spirometry |
author_facet |
Petra Um-Bergström Jenny Hallberg Melvin Pourbazargan Eva Berggren-Broström Giovanni Ferrara Maria J. Eriksson Sven Nyrén Jing Gao Gunnar Lilja Anders Lindén Åsa M. Wheelock Erik Melén C. Magnus Sköld |
author_sort |
Petra Um-Bergström |
title |
Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma |
title_short |
Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma |
title_full |
Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma |
title_fullStr |
Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma |
title_full_unstemmed |
Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma |
title_sort |
pulmonary outcomes in adults with a history of bronchopulmonary dysplasia differ from patients with asthma |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2019-05-01 |
description |
Abstract Background Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypothesized that pulmonary outcomes and health-related quality of life (HRQoL) were different in adults born preterm with and without a history of BPD compared to asthmatics and healthy individuals. Methods We evaluated 96 young adults from the LUNAPRE cohort (clinicaltrials.gov/ct2/show/NCT02923648), including 26 individuals born preterm with a history of BPD (BPD), 23 born preterm without BPD (preterm), 23 asthmatics and 24 healthy controls. Extensive lung function testing and HRQoL were assessed. Results The BPD group had more severe airway obstruction compared to the preterm-, (FEV1− 0.94 vs. 0.28 z-scores; p ≤ 0.001); asthmatic- (0.14 z-scores, p ≤ 0.01) and healthy groups (0.78 z-scores, p ≤ 0.001). Further, they had increased ventilation inhomogeneity compared to the preterm- (LCI 6.97 vs. 6.73, p ≤ 0.05), asthmatic- (6.75, p = 0.05) and healthy groups (6.50 p ≤ 0.001). Both preterm groups had lower DLCO compared to healthy controls (p ≤ 0.001 for both). HRQoL showed less physical but more psychological symptoms in the BPD group compared to asthmatics. Conclusions Lung function impairment and HRQoL in adults with a history of BPD differed from that in asthmatics highlighting the need for objective assessment of lung health. |
topic |
Bronchopulmonary dysplasia Adults Astma Lung function tests Oscillometry Spirometry |
url |
http://link.springer.com/article/10.1186/s12931-019-1075-1 |
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