p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.

Bibliographic Details
Main Authors: Marina E. Borisova, Andrea Voigt, Maxim A. X. Tollenaere, Sanjeeb Kumar Sahu, Thomas Juretschke, Nastasja Kreim, Niels Mailand, Chunaram Choudhary, Simon Bekker-Jensen, Masato Akutsu, Sebastian A. Wagner, Petra Beli
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03417-3
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spelling doaj-1c38a6be3fea435e8a20721ee33028332021-05-11T10:01:11ZengNature Publishing GroupNature Communications2041-17232018-03-019111610.1038/s41467-018-03417-3p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damageMarina E. Borisova0Andrea Voigt1Maxim A. X. Tollenaere2Sanjeeb Kumar Sahu3Thomas Juretschke4Nastasja Kreim5Niels Mailand6Chunaram Choudhary7Simon Bekker-Jensen8Masato Akutsu9Sebastian A. Wagner10Petra Beli11Institute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)Cellular Stress Signaling Group, Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of CopenhagenInstitute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)Ubiquitin Signaling Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of CopenhagenProteomics and Cell Signaling Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of CopenhagenCellular Stress Signaling Group, Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of CopenhagenInstitute of Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt and Buchmann Institute for Molecular Life Sciences (BMLS), Goethe UniversityDepartment of Medicine, Hematology/Oncology, Goethe UniversityInstitute of Molecular Biology (IMB)UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.https://doi.org/10.1038/s41467-018-03417-3
collection DOAJ
language English
format Article
sources DOAJ
author Marina E. Borisova
Andrea Voigt
Maxim A. X. Tollenaere
Sanjeeb Kumar Sahu
Thomas Juretschke
Nastasja Kreim
Niels Mailand
Chunaram Choudhary
Simon Bekker-Jensen
Masato Akutsu
Sebastian A. Wagner
Petra Beli
spellingShingle Marina E. Borisova
Andrea Voigt
Maxim A. X. Tollenaere
Sanjeeb Kumar Sahu
Thomas Juretschke
Nastasja Kreim
Niels Mailand
Chunaram Choudhary
Simon Bekker-Jensen
Masato Akutsu
Sebastian A. Wagner
Petra Beli
p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Nature Communications
author_facet Marina E. Borisova
Andrea Voigt
Maxim A. X. Tollenaere
Sanjeeb Kumar Sahu
Thomas Juretschke
Nastasja Kreim
Niels Mailand
Chunaram Choudhary
Simon Bekker-Jensen
Masato Akutsu
Sebastian A. Wagner
Petra Beli
author_sort Marina E. Borisova
title p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_short p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_full p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_fullStr p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_full_unstemmed p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_sort p38-mk2 signaling axis regulates rna metabolism after uv-light-induced dna damage
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.
url https://doi.org/10.1038/s41467-018-03417-3
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