Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant <it>Staphylococcus aureus </it>in a renal transplant recipient with Fabry-Anderson disease

• Main Authors: Polilli Ennio, Ursini Tamara, Mazzotta Elena, Sozio Federica, Savini Vincenzo, D'Antonio Domenico, Barbato Michelino, Consorte Augusta, Parruti Giustino
• Format: Article
• Language: English
• Published: BMC 2012-03-01
• Series: Annals of Clinical Microbiology and Antimicrobials
• Subjects: Methicillin-resistant <it>Staphylococcus aureus</it>; Osteomyelitis; Daptomycin; Salvage therapy; Antibiotic therapy
• Online Access: http://www.ann-clinmicrob.com/content/11/1/6
• ISSN: 1476-0711

<p>Abstract</p> <p>Daptomycin is licensed in adults for the management of <it>Staphylococcus aureus </it>methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/qd for 4 weeks. Local debridement was performed in advance of each line of treatment.</p>