The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension
Context: Oxidative Stress is caused by an imbalance between the production of reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates. Aims: 1. To compare the levels of Malondialdehyde (MDA), in hypertensive and normotensive subjects. 2. To compar...
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doaj-1c3b4a7e1a344e32a68fb07b05b5914d2020-11-25T02:58:56ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-06-017698799010.7860/JCDR/2013/5829.3091The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential HypertensionAquil Ahmad0Usha Singhal1Mohd Mobark Hossain2Najmul Islam3Imran Rizvi4Department of Physiology, JNMC, AMU, Aligarh, UP-202002, India.Department of Physiology, JNMC, AMU, Aligarh, UP-202002, India.Department of Physiology, JNMC, AMU, Aligarh, UP-202002, India.Department of Biochemistry, JNMC, AMU, Aligarh, UP-202002, India.Department of Medicine, JNMC, AMU, Aligarh, UP-202002, India.Context: Oxidative Stress is caused by an imbalance between the production of reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates. Aims: 1. To compare the levels of Malondialdehyde (MDA), in hypertensive and normotensive subjects. 2. To compare the levels of the antioxidant enzymes, namely, Catalase, Glutathione peroxidase (GPX) and Superoxide Dismutase (SOD) in hypertensive and normotensive subjects. 3. To determine the correlation between the MDA levels and the mean arterial pressure (MAP) among hypertensive subjects. 4. To determine the correlation between the antioxidant enzyme levels and MAP among the hypertensive subjects and to evaluate the effect of 6 months of antihypertensive therapy with a tight blood pressure control on the MDA levels. Materials and Methods: In this cross sectional study, 25 normotensive and 40 hypertensive subjects were recruited. The hypertensive subjects were further subdivided into three subgroups: Prehypertensives, Stage I hypertensives and Stage II hypertensives. All the subjects underwent a blood pressure measurement and the markers of oxidative stress in their sera were estimated. The subjects of Stage I hypertension and Stage II hypertension were given antihypertensive treatment for 6 months and their blood pressures were tightly regulated and brought to the normotensive state. After 6 months, the estimations of the markers of oxidative stress were done again. Results: The MDA levels were significantly increased in the stage I and stage II hypertension groups as compared to those of the control group (p<0.05). The antioxidant enzymes (SOD, Catalase and GPX) were significantly decreased (p<0.05) in the prehypertension and in the stage I and stage II hypertension groups as compared to those in the control group. There was a significant increase in the levels of the antioxidant enzymes after 6 months of a tight regulation and bringing of the blood pressure to the normotensive state by giving antihypertensive therapy. Conclusion: On comparison of the present study with other studies in which the use of antioxidants were found to be ineffective in the blood pressure reduction, it can be concluded that oxidative stress is an effect rather than a cause of essential hypertension.https://jcdr.net/articles/PDF/3091/4%20-%205829_E(C)_PF1(PU)_F(H)_PF1(PUH)_PFA(NC)_OLF_u.pdfessential hypertensionoxidative stresscatalaseglutathione peroxidasesuperoxide dismutase antihypertensive therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aquil Ahmad Usha Singhal Mohd Mobark Hossain Najmul Islam Imran Rizvi |
spellingShingle |
Aquil Ahmad Usha Singhal Mohd Mobark Hossain Najmul Islam Imran Rizvi The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension Journal of Clinical and Diagnostic Research essential hypertension oxidative stress catalase glutathione peroxidase superoxide dismutase antihypertensive therapy |
author_facet |
Aquil Ahmad Usha Singhal Mohd Mobark Hossain Najmul Islam Imran Rizvi |
author_sort |
Aquil Ahmad |
title |
The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension |
title_short |
The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension |
title_full |
The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension |
title_fullStr |
The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension |
title_full_unstemmed |
The Role of the Endogenous Antioxidant Enzymes and Malondialdehyde in Essential Hypertension |
title_sort |
role of the endogenous antioxidant enzymes and malondialdehyde in essential hypertension |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2013-06-01 |
description |
Context: Oxidative Stress is caused by an imbalance between
the production of reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates.
Aims: 1. To compare the levels of Malondialdehyde (MDA), in
hypertensive and normotensive subjects.
2. To compare the levels of the antioxidant enzymes, namely,
Catalase, Glutathione peroxidase (GPX) and Superoxide Dismutase (SOD) in hypertensive and normotensive subjects.
3. To determine the correlation between the MDA levels and the
mean arterial pressure (MAP) among hypertensive subjects.
4. To determine the correlation between the antioxidant enzyme levels and MAP among the hypertensive subjects and
to evaluate the effect of 6 months of antihypertensive therapy
with a tight blood pressure control on the MDA levels.
Materials and Methods: In this cross sectional study, 25 normotensive and 40 hypertensive subjects were recruited. The
hypertensive subjects were further subdivided into three subgroups: Prehypertensives, Stage I hypertensives and Stage II
hypertensives. All the subjects underwent a blood pressure
measurement and the markers of oxidative stress in their sera
were estimated. The subjects of Stage I hypertension and
Stage II hypertension were given antihypertensive treatment
for 6 months and their blood pressures were tightly regulated
and brought to the normotensive state. After 6 months, the estimations of the markers of oxidative stress were done again.
Results: The MDA levels were significantly increased in the
stage I and stage II hypertension groups as compared to those
of the control group (p<0.05). The antioxidant enzymes (SOD,
Catalase and GPX) were significantly decreased (p<0.05) in the
prehypertension and in the stage I and stage II hypertension
groups as compared to those in the control group. There was
a significant increase in the levels of the antioxidant enzymes
after 6 months of a tight regulation and bringing of the blood
pressure to the normotensive state by giving antihypertensive
therapy.
Conclusion: On comparison of the present study with other
studies in which the use of antioxidants were found to be ineffective in the blood pressure reduction, it can be concluded
that oxidative stress is an effect rather than a cause of essential hypertension. |
topic |
essential hypertension oxidative stress catalase glutathione peroxidase superoxide dismutase antihypertensive therapy |
url |
https://jcdr.net/articles/PDF/3091/4%20-%205829_E(C)_PF1(PU)_F(H)_PF1(PUH)_PFA(NC)_OLF_u.pdf |
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