Cell Uptake and Biocompatibility of Nanoparticles Prepared from Poly(benzyl malate) (Co)polymers Obtained through Chemical and Enzymatic Polymerization in Human HepaRG Cells and Primary Macrophages

Cell Uptake and Biocompatibility of Nanoparticles Prepared from Poly(benzyl malate) (Co)polymers Obtained through Chemical and Enzymatic Polymerization in Human HepaRG Cells and Primary Macrophages

The design of drug-loaded nanoparticles (NPs) appears to be a suitable strategy for the prolonged plasma concentration of therapeutic payloads, higher bioavailability, and the reduction of side effects compared with classical chemotherapies. In most cases, NPs are prepared from (co)polymers obtained...

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Bibliographic Details
Main Authors: Hubert Casajus, Saad Saba, Manuel Vlach, Elise Vène, Catherine Ribault, Sylvain Tranchimand, Caroline Nugier-Chauvin, Eric Dubreucq, Pascal Loyer, Sandrine Cammas-Marion, Nicolas Lepareur
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Polymers
Subjects:
enzymatic polymerization
chemical polymerization
poly(benzyl malate)
biocompatible nanoparticles
cell uptake
cytotoxicity
HepaRG cells
human macrophages
Online Access:https://www.mdpi.com/2073-4360/10/11/1244

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