Pilot experience of using modified high-dose therapy NHL-BFM-90 in diffuse large B-cell lymphosarcoma with primary skin involvement. A case report

• Main Authors: Varvara Ivanovna Zamyatina, Aminat Umaraskhabovna Magomedova, Sergey Kirillovich Kravchenko, Elena Aleksandrovna Gilyazitdinova, Elena Alekseevna Ilyushkina, Evgeniy Evgen'evich Zvonkov, Irina Borisovna Kaplanskaya, Tat'yana Nikiforovna Obukhova, Galina Aleksandrovna Klyasova, Lana Anzorovna Gorgidze, Zhanna Valentinovna Churakova, Aleksandra Mikhaylovna Kremenetskaya, Andrey Ivanovich Vorob'ev, V I Zamyatina, A U Magomedova, S K Kravchenko, E A Gilyazitdinova, E A Ilyushkina, E E Zvonkov, I B Kaplanskaya, T N Obukhova, G A Klyasova, L A Gorgidze, Zh V Churakova, A M Kremenetskaya, A I Vorobyev
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2009-07-01
• Series: Терапевтический архив
• Subjects: primary large b-cell skin lymphosarcoma; polychemotherapy; high-dose therapy; nhl bfm-90
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/30421

Primary skin large B-cell lymphosarcomas (PLBCL) present with skin lesions, other organs and systems are not involved. As CHOP courses are not high effective in PLBCL, we were the first to treat a patient with modified block therapy NHL BFM-90. A complete remission was achieved after the first course of polychemotherapy and was consolidated by two courses of treatment. Further follow-up is needed.