Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes
Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavie...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | Prostate Cancer |
Online Access: | http://dx.doi.org/10.1155/2014/186782 |
id |
doaj-1c3c35c4cf1a4e91a43a35a869132c54 |
---|---|
record_format |
Article |
spelling |
doaj-1c3c35c4cf1a4e91a43a35a869132c542020-11-24T22:49:57ZengHindawi LimitedProstate Cancer2090-31112090-312X2014-01-01201410.1155/2014/186782186782Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year OutcomesKsenija Limani0Fouad Aoun1Serge Holz2Marianne Paesmans3Alexandre Peltier4Roland van Velthoven5Department of Urology, Jules Bordet Institute, 1 Rue Héger-Bordet, 1000 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, 1 Rue Héger-Bordet, 1000 Brussels, BelgiumUniversité Libre de Bruxelles, 50 Franklin Roosevelt Avenue, 1050 Brussels, BelgiumDepartment of Data Management, Jules Bordet Institute, 1 Rue Héger-Bordet, 1000 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, 1 Rue Héger-Bordet, 1000 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, 1 Rue Héger-Bordet, 1000 Brussels, BelgiumObjectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4%) and 50 (46.3%) patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year actuarial biochemical recurrence free survival rates were 57% and 40%, respectively. The 10-year overall survival rate, cancer specific survival rate, and metastasis free survival rate were 72%, 90%, and 70%, respectively. Preoperative high risk category, Gleason score, preoperative PSA, and postoperative nadir PSA were independent predictors of oncological failure. 24.5% of patients had self-resolving LUTS, 18.2% had urinary tract infection, and 18.2% had acute urinary retention. A grade 3b complication occurred in 27 patients. Pad-free continence rate was 87.9% and the erectile dysfunction rate was 30.8%. Conclusion. Single session HIFU can be alternative therapy for patients with low risk PCa. Patients with intermediate risk should be informed about the need of multiple sessions of HIFU and/or adjuvant treatments and HIFU performed very poorly in high risk patients.http://dx.doi.org/10.1155/2014/186782 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ksenija Limani Fouad Aoun Serge Holz Marianne Paesmans Alexandre Peltier Roland van Velthoven |
spellingShingle |
Ksenija Limani Fouad Aoun Serge Holz Marianne Paesmans Alexandre Peltier Roland van Velthoven Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes Prostate Cancer |
author_facet |
Ksenija Limani Fouad Aoun Serge Holz Marianne Paesmans Alexandre Peltier Roland van Velthoven |
author_sort |
Ksenija Limani |
title |
Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes |
title_short |
Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes |
title_full |
Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes |
title_fullStr |
Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes |
title_full_unstemmed |
Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes |
title_sort |
single high intensity focused ultrasound session as a whole gland primary treatment for clinically localized prostate cancer: 10-year outcomes |
publisher |
Hindawi Limited |
series |
Prostate Cancer |
issn |
2090-3111 2090-312X |
publishDate |
2014-01-01 |
description |
Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4%) and 50 (46.3%) patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year actuarial biochemical recurrence free survival rates were 57% and 40%, respectively. The 10-year overall survival rate, cancer specific survival rate, and metastasis free survival rate were 72%, 90%, and 70%, respectively. Preoperative high risk category, Gleason score, preoperative PSA, and postoperative nadir PSA were independent predictors of oncological failure. 24.5% of patients had self-resolving LUTS, 18.2% had urinary tract infection, and 18.2% had acute urinary retention. A grade 3b complication occurred in 27 patients. Pad-free continence rate was 87.9% and the erectile dysfunction rate was 30.8%. Conclusion. Single session HIFU can be alternative therapy for patients with low risk PCa. Patients with intermediate risk should be informed about the need of multiple sessions of HIFU and/or adjuvant treatments and HIFU performed very poorly in high risk patients. |
url |
http://dx.doi.org/10.1155/2014/186782 |
work_keys_str_mv |
AT ksenijalimani singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes AT fouadaoun singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes AT sergeholz singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes AT mariannepaesmans singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes AT alexandrepeltier singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes AT rolandvanvelthoven singlehighintensityfocusedultrasoundsessionasawholeglandprimarytreatmentforclinicallylocalizedprostatecancer10yearoutcomes |
_version_ |
1725674301111140352 |