Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study
Action observation therapy has recently attracted increasing attention; however, the mechanisms through which action observation and execution (AOE) modulate neural activity in stroke patients remain unclear. This study was aimed at investigating the effects of action observation and two types of AO...
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2019/8481371 |
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doaj-1c41825f8ccc4075a7366cbb030d16022020-11-24T21:50:07ZengHindawi LimitedNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/84813718481371Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG StudyJun-Ding Zhu0Chia-Hsiung Cheng1Yi-Jhan Tseng2Chien-Chen Chou3Chih-Chi Chen4Yu-Wei Hsieh5Yu-Hsien Liao6Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu, TaiwanEpilepsy Division, Neurological Institute, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, TaiwanDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, TaiwanAction observation therapy has recently attracted increasing attention; however, the mechanisms through which action observation and execution (AOE) modulate neural activity in stroke patients remain unclear. This study was aimed at investigating the effects of action observation and two types of AOE on motor cortical activations after stroke using magnetoencephalography. Twenty patients with stroke and 20 healthy controls were recruited for the collection of data on the beta oscillatory activity in the primary motor cortex (M1). All participants performed the conditions of resting, observation only, and video observation combined with execution (video AOE). Stroke patients performed one additional condition of affected hand observation combined with execution (affected hand AOE). The relative change index of beta oscillations was calculated, and nonparametric tests were used to examine the differences in conditions. In stroke patients, the relative change index of M1 beta oscillatory activity under the video AOE condition was significantly lower than that under the observation only and affected hand AOE conditions. Moreover, M1 cortical activity did not significantly differ under the observation only and affected hand AOE conditions. For healthy controls, the relative change index under the video AOE condition was significantly lower than that under the observation only condition. In addition, no significant differences in relative change indices were found under the observation only and video AOE conditions between the 2 groups. This study provides new insight into the neural mechanisms underlying AOE, which supports the use of observing videos of normal movements during action observation therapy in stroke rehabilitation.http://dx.doi.org/10.1155/2019/8481371 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun-Ding Zhu Chia-Hsiung Cheng Yi-Jhan Tseng Chien-Chen Chou Chih-Chi Chen Yu-Wei Hsieh Yu-Hsien Liao |
spellingShingle |
Jun-Ding Zhu Chia-Hsiung Cheng Yi-Jhan Tseng Chien-Chen Chou Chih-Chi Chen Yu-Wei Hsieh Yu-Hsien Liao Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study Neural Plasticity |
author_facet |
Jun-Ding Zhu Chia-Hsiung Cheng Yi-Jhan Tseng Chien-Chen Chou Chih-Chi Chen Yu-Wei Hsieh Yu-Hsien Liao |
author_sort |
Jun-Ding Zhu |
title |
Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study |
title_short |
Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study |
title_full |
Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study |
title_fullStr |
Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study |
title_full_unstemmed |
Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study |
title_sort |
modulation of motor cortical activities by action observation and execution in patients with stroke: an meg study |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
2090-5904 1687-5443 |
publishDate |
2019-01-01 |
description |
Action observation therapy has recently attracted increasing attention; however, the mechanisms through which action observation and execution (AOE) modulate neural activity in stroke patients remain unclear. This study was aimed at investigating the effects of action observation and two types of AOE on motor cortical activations after stroke using magnetoencephalography. Twenty patients with stroke and 20 healthy controls were recruited for the collection of data on the beta oscillatory activity in the primary motor cortex (M1). All participants performed the conditions of resting, observation only, and video observation combined with execution (video AOE). Stroke patients performed one additional condition of affected hand observation combined with execution (affected hand AOE). The relative change index of beta oscillations was calculated, and nonparametric tests were used to examine the differences in conditions. In stroke patients, the relative change index of M1 beta oscillatory activity under the video AOE condition was significantly lower than that under the observation only and affected hand AOE conditions. Moreover, M1 cortical activity did not significantly differ under the observation only and affected hand AOE conditions. For healthy controls, the relative change index under the video AOE condition was significantly lower than that under the observation only condition. In addition, no significant differences in relative change indices were found under the observation only and video AOE conditions between the 2 groups. This study provides new insight into the neural mechanisms underlying AOE, which supports the use of observing videos of normal movements during action observation therapy in stroke rehabilitation. |
url |
http://dx.doi.org/10.1155/2019/8481371 |
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