Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacity

• Main Authors: Olivier Briet, Hannah Koenker, Laura Norris, Ryan Wiegand, Jodi Vanden Eng, Alex Thackeray, John Williamson, John E. Gimnig, Filomeno Fortes, Martin Akogbeto, Anges W. Yadouleton, Maurice Ombok, M. Nabie Bayoh, Themba Mzilahowa, Ana Paula Abílio, Samuel Mabunda, Nelson Cuamba, Elhadji Diouf, Lassana Konaté, Busiku Hamainza, Cecilia Katebe-Sakala, Gabriel Ponce de León, Kwame Asamoa, Adam Wolkon, Stephen C. Smith, Isabel Swamidoss, Mike Green, Salam Gueye, Jules Mihigo, Juliette Morgan, Ellen Dotson, Allen S. Craig, Kathrine R. Tan, Robert A. Wirtz, Tom Smith
• Format: Article
• Language: English
• Published: BMC 2020-08-01
• Series: Malaria Journal
• Subjects: Long-lasting insecticidal nets; Durability monitoring; Vectorial capacity; Malaria
• Online Access: http://link.springer.com/article/10.1186/s12936-020-03383-6

Abstract Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physically damaged, or lose insecticidal activity. The contributions of these different interrelated factors to durability of nets and their protection against malaria have been unclear. Methods Starting in 2009, LLIN durability studies were conducted in seven countries in Africa over 5 years. WHO-recommended measures of attrition, LLIN use, insecticidal activity, and physical integrity were recorded for eight different net brands. These data were combined with analyses of experimental hut data on feeding inhibition and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission—in terms of vectorial capacity (VC)—provided by each net cohort over time. Impact on VC was then compared in hypothetical scenarios where one durability outcome measure was set at the best possible level while keeping the others at the observed levels. Results There was more variability in decay of protection over time by country than by net brand for three measures of durability (ratios of variance components 4.6, 4.4, and 1.8 times for LLIN survival, use, and integrity, respectively). In some countries, LLIN attrition was slow, but use declined rapidly. Non-use of LLINs generally had more effect on LLIN impact on VC than did attrition, hole formation, or insecticide loss. Conclusions There is much more variation in LLIN durability among countries than among net brands. Low levels of use may have a larger impact on effectiveness than does variation in attrition or LLIN degradation. The estimated entomological effects of chemical decay are relatively small, with physical decay probably more important as a driver of attrition and non-use than as a direct cause of loss of effect. Efforts to maximize LLIN impact in operational settings should focus on increasing LLIN usage, including through improvements in LLIN physical integrity. Further research is needed to understand household decisions related to LLIN use, including the influence of net durability and the presence of other nets in the household.