Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study
Abstract Background The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus. This research aimed to uncover the role of adipsin in Chinese type 2...
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doaj-1c46bf07716b4ddfb8bafc6f981164ba2020-11-25T03:56:18ZengBMCBMC Endocrine Disorders1472-68232019-10-011911910.1186/s12902-019-0431-yAssociation between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional studyDan Guo0Yang Yuan1Rong Huang2Sai Tian3Jiaqi Wang4Hongyan Lin5Ke An6Jin Han7Shaohua Wang8Department of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityDepartment of Endocrinology, Affiliated Zhongda Hospital of Southeast UniversityAbstract Background The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus. This research aimed to uncover the role of adipsin in Chinese type 2 diabetes mellitus (T2DM) population with early cognitive dysfunction and determine whether adipsin contributes to diabetic MCI caused by IR. Methods In our study, 126 patients with T2DM were enrolled. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive impairment. Demographic data and neuropsychological test results were evaluated. Plasma adipsin level was measured by enzyme-linked immunosorbent assay. Results The MCI group (n = 57) presented higher plasma adipsin levels compared with the healthy controls (p = 0.018). After adjustment for educational attainment, and age, begative correlations were found between plasma adipsin levels and MoCA, Mini Mental State Exam, and Verbal Fluency Test scores(r = − 0.640, p < 0.001; r = − 0.612, p < 0.001; r = − 0.288, p = 0.035; respectively). Correlation analysis demonstrated that adipsin levels were significantly positively correlated with fasting C-peptide; homeostasis model of assessment for insulin resistance (HOMA-IR) (r = 0.368, p < 0.001; r = 0.494, p < 0.001; respectively). Multivariable regression analysis further indicated that high plasma adipsin level was a significant independent determinant of MCI in the Chinese population withT2DM (p = 0.017). Conclusions Elevated plasma adipsin level was associated with MCI in Chinese T2DM patients. Further large-scale studies should be designed to determine whether adipsin is linked to IR-associated susceptibility to early cognitive decline in T2DM patients.http://link.springer.com/article/10.1186/s12902-019-0431-yAdipsinHomeostasis model of assessment for insulin resistanceMild cognitive impairmentType 2 diabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dan Guo Yang Yuan Rong Huang Sai Tian Jiaqi Wang Hongyan Lin Ke An Jin Han Shaohua Wang |
spellingShingle |
Dan Guo Yang Yuan Rong Huang Sai Tian Jiaqi Wang Hongyan Lin Ke An Jin Han Shaohua Wang Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study BMC Endocrine Disorders Adipsin Homeostasis model of assessment for insulin resistance Mild cognitive impairment Type 2 diabetes mellitus |
author_facet |
Dan Guo Yang Yuan Rong Huang Sai Tian Jiaqi Wang Hongyan Lin Ke An Jin Han Shaohua Wang |
author_sort |
Dan Guo |
title |
Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study |
title_short |
Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study |
title_full |
Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study |
title_fullStr |
Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study |
title_full_unstemmed |
Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study |
title_sort |
association between plasma adipsin level and mild cognitive impairment in chinese patients with type 2 diabetes: a cross-sectional study |
publisher |
BMC |
series |
BMC Endocrine Disorders |
issn |
1472-6823 |
publishDate |
2019-10-01 |
description |
Abstract Background The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus. This research aimed to uncover the role of adipsin in Chinese type 2 diabetes mellitus (T2DM) population with early cognitive dysfunction and determine whether adipsin contributes to diabetic MCI caused by IR. Methods In our study, 126 patients with T2DM were enrolled. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive impairment. Demographic data and neuropsychological test results were evaluated. Plasma adipsin level was measured by enzyme-linked immunosorbent assay. Results The MCI group (n = 57) presented higher plasma adipsin levels compared with the healthy controls (p = 0.018). After adjustment for educational attainment, and age, begative correlations were found between plasma adipsin levels and MoCA, Mini Mental State Exam, and Verbal Fluency Test scores(r = − 0.640, p < 0.001; r = − 0.612, p < 0.001; r = − 0.288, p = 0.035; respectively). Correlation analysis demonstrated that adipsin levels were significantly positively correlated with fasting C-peptide; homeostasis model of assessment for insulin resistance (HOMA-IR) (r = 0.368, p < 0.001; r = 0.494, p < 0.001; respectively). Multivariable regression analysis further indicated that high plasma adipsin level was a significant independent determinant of MCI in the Chinese population withT2DM (p = 0.017). Conclusions Elevated plasma adipsin level was associated with MCI in Chinese T2DM patients. Further large-scale studies should be designed to determine whether adipsin is linked to IR-associated susceptibility to early cognitive decline in T2DM patients. |
topic |
Adipsin Homeostasis model of assessment for insulin resistance Mild cognitive impairment Type 2 diabetes mellitus |
url |
http://link.springer.com/article/10.1186/s12902-019-0431-y |
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