Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT). CDT displays dual DNase and phosphatase activities and induces DNA double stran...

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Bibliographic Details
Main Authors: Vanessa eGraillot, Inge eDormoy, Jacques eDupuy, Jerry eShay, Laurence eHuc, Gladys eMirey, Julien eVignard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
APC
colorectal cancer
Genotoxicity
KRAS
p53
cytolethal distending toxin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00034/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00034/full

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