Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance...
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Canadian Society for Pharmaceutical Sciences
2011-02-01
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doaj-1c77a2808f9545adb4d0f8d4f593111e2020-11-25T04:01:26ZengCanadian Society for Pharmaceutical SciencesJournal of Pharmacy & Pharmaceutical Sciences1482-18262011-02-0114110.18433/J30C7DNanotherapeutics to Overcome Conventional Cancer Chemotherapy LimitationsMoorthi ChidambaramR. ManavalanK. KathiresanCancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/9199 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moorthi Chidambaram R. Manavalan K. Kathiresan |
spellingShingle |
Moorthi Chidambaram R. Manavalan K. Kathiresan Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations Journal of Pharmacy & Pharmaceutical Sciences |
author_facet |
Moorthi Chidambaram R. Manavalan K. Kathiresan |
author_sort |
Moorthi Chidambaram |
title |
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations |
title_short |
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations |
title_full |
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations |
title_fullStr |
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations |
title_full_unstemmed |
Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations |
title_sort |
nanotherapeutics to overcome conventional cancer chemotherapy limitations |
publisher |
Canadian Society for Pharmaceutical Sciences |
series |
Journal of Pharmacy & Pharmaceutical Sciences |
issn |
1482-1826 |
publishDate |
2011-02-01 |
description |
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy. |
url |
https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/9199 |
work_keys_str_mv |
AT moorthichidambaram nanotherapeuticstoovercomeconventionalcancerchemotherapylimitations AT rmanavalan nanotherapeuticstoovercomeconventionalcancerchemotherapylimitations AT kkathiresan nanotherapeuticstoovercomeconventionalcancerchemotherapylimitations |
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