Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese
Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help devel...
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Format: | Article |
Language: | English |
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MDPI AG
2021-06-01
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Series: | Journal of Personalized Medicine |
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Online Access: | https://www.mdpi.com/2075-4426/11/7/614 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoni Meng Manshu Song Marija Vilaj Jerko Štambuk Mamatyusupu Dolikun Jie Zhang Di Liu Hao Wang Xiaoyu Zhang Jinxia Zhang Weijie Cao Ana Momčilović Irena Trbojević-Akmačić Xingang Li Deqiang Zheng Lijuan Wu Xiuhua Guo Youxin Wang Gordan Lauc Wei Wang |
spellingShingle |
Xiaoni Meng Manshu Song Marija Vilaj Jerko Štambuk Mamatyusupu Dolikun Jie Zhang Di Liu Hao Wang Xiaoyu Zhang Jinxia Zhang Weijie Cao Ana Momčilović Irena Trbojević-Akmačić Xingang Li Deqiang Zheng Lijuan Wu Xiuhua Guo Youxin Wang Gordan Lauc Wei Wang Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese Journal of Personalized Medicine hypertension and type 2 diabetes mellitus comorbidity IgG N-glycosylation biomarkers |
author_facet |
Xiaoni Meng Manshu Song Marija Vilaj Jerko Štambuk Mamatyusupu Dolikun Jie Zhang Di Liu Hao Wang Xiaoyu Zhang Jinxia Zhang Weijie Cao Ana Momčilović Irena Trbojević-Akmačić Xingang Li Deqiang Zheng Lijuan Wu Xiuhua Guo Youxin Wang Gordan Lauc Wei Wang |
author_sort |
Xiaoni Meng |
title |
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese |
title_short |
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese |
title_full |
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese |
title_fullStr |
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese |
title_full_unstemmed |
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese |
title_sort |
glycosylation of igg associates with hypertension and type 2 diabetes mellitus comorbidity in the chinese muslim ethnic minorities and the han chinese |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2021-06-01 |
description |
Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help develop novel protective immune-targeted and anti-inflammatory therapies. Therefore, we investigated glycosylation changes of IgG associated with HDC. Methods: The IgG N-glycan profiles of 883 plasma samples from the three northwestern Chinese Muslim ethnic minorities and the Han Chinese were analyzed by ultra-performance liquid chromatography instrument. Results: We found that 12 and six IgG N-glycan traits showed significant associations with HDC in the Chinese Muslim ethnic minorities and the Han Chinese, respectively, after adjustment for potential confounders and false discovery rate. Adding the IgG N-glycan traits to the baseline models, the area under the receiver operating characteristic curves (AUCs) of the combined models differentiating HDC from hypertension (HTN), type 2 diabetes mellitus (T2DM), and healthy individuals were 0.717, 0.747, and 0.786 in the pooled samples of Chinese Muslim ethnic minorities, and 0.828, 0.689, and 0.901 in the Han Chinese, respectively, showing improved discriminating performance than both the baseline models and the glycan-based models. Conclusion: Altered IgG N-glycan profiles were shown to associate with HDC, suggesting the involvement of inflammatory processes of IgG glycosylation. The alterations of IgG N-glycome, illustrated here for the first time in HDC, demonstrate a biomarker potential, which may shed light on future studies investigating their potential for monitoring or preventing the progression from HTN or T2DM towards HDC. |
topic |
hypertension and type 2 diabetes mellitus comorbidity IgG N-glycosylation biomarkers |
url |
https://www.mdpi.com/2075-4426/11/7/614 |
work_keys_str_mv |
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doaj-1c7b9540a2b34cd5b2c773b8dc01a1ef2021-07-23T13:49:24ZengMDPI AGJournal of Personalized Medicine2075-44262021-06-011161461410.3390/jpm11070614Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han ChineseXiaoni Meng0Manshu Song1Marija Vilaj2Jerko Štambuk3Mamatyusupu Dolikun4Jie Zhang5Di Liu6Hao Wang7Xiaoyu Zhang8Jinxia Zhang9Weijie Cao10Ana Momčilović11Irena Trbojević-Akmačić12Xingang Li13Deqiang Zheng14Lijuan Wu15Xiuhua Guo16Youxin Wang17Gordan Lauc18Wei Wang19Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaGenos Glycoscience Research Laboratory, 10000 Zagreb, CroatiaGenos Glycoscience Research Laboratory, 10000 Zagreb, CroatiaCollege of the Life Sciences and Technology, Xinjiang University, Urumqi 830046, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaDepartment of Clinical Epidemiology and Evidence-Based Medicine, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaGenos Glycoscience Research Laboratory, 10000 Zagreb, CroatiaGenos Glycoscience Research Laboratory, 10000 Zagreb, CroatiaSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA 6027, AustraliaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaGenos Glycoscience Research Laboratory, 10000 Zagreb, CroatiaBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, ChinaObjectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help develop novel protective immune-targeted and anti-inflammatory therapies. Therefore, we investigated glycosylation changes of IgG associated with HDC. Methods: The IgG N-glycan profiles of 883 plasma samples from the three northwestern Chinese Muslim ethnic minorities and the Han Chinese were analyzed by ultra-performance liquid chromatography instrument. Results: We found that 12 and six IgG N-glycan traits showed significant associations with HDC in the Chinese Muslim ethnic minorities and the Han Chinese, respectively, after adjustment for potential confounders and false discovery rate. Adding the IgG N-glycan traits to the baseline models, the area under the receiver operating characteristic curves (AUCs) of the combined models differentiating HDC from hypertension (HTN), type 2 diabetes mellitus (T2DM), and healthy individuals were 0.717, 0.747, and 0.786 in the pooled samples of Chinese Muslim ethnic minorities, and 0.828, 0.689, and 0.901 in the Han Chinese, respectively, showing improved discriminating performance than both the baseline models and the glycan-based models. Conclusion: Altered IgG N-glycan profiles were shown to associate with HDC, suggesting the involvement of inflammatory processes of IgG glycosylation. The alterations of IgG N-glycome, illustrated here for the first time in HDC, demonstrate a biomarker potential, which may shed light on future studies investigating their potential for monitoring or preventing the progression from HTN or T2DM towards HDC.https://www.mdpi.com/2075-4426/11/7/614hypertension and type 2 diabetes mellitus comorbidityIgGN-glycosylationbiomarkers |