Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats
Introduction: This study investigated an interaction between acute restraint stress and verapamil, as a blocker of L-type voltage sensitive channels on retrieval of long-term memory. Materials and Methods: Young adult male rats were trained in one trial inhibitory avoidance task (1mA, 1.5s footshock...
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Semnan Univeristy of Medical Sciences
2006-11-01
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doaj-1c84756d576c48b8aa9f9405803fa30c2020-11-25T00:53:50ZfasSemnan Univeristy of Medical SciencesMajallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān1608-70462006-11-0108018590Verapamil enhances the impairing effects of stress on retrieval of long-term memory in ratsA. Rashidy-PourA.A. TaherianA.A. VafaeiH. Miladi-GorjiH. SadeghiY. FathollahiA.R. BandehgiIntroduction: This study investigated an interaction between acute restraint stress and verapamil, as a blocker of L-type voltage sensitive channels on retrieval of long-term memory. Materials and Methods: Young adult male rats were trained in one trial inhibitory avoidance task (1mA, 1.5s footshock). On retention test given 48 hr after training, the latency to re-enter dark compartment and time spent in light chamber of the apparatus were recorded. Thirty min before retention test, the rats were exposed to a 10 min of restraint stress in a Plexiglass with or without prior treatment of verapamil (5, 10, 20 mg/kg). Results: The results showed verapamil pretreatment enhanced the impairing effect of stress on memory retrieval. The applied stress increased circulating corticosterone levels as assessed immediately after the retention test, indicating that stress–induced impairment of memory retrieval is mediated, in part, by increased plasma levels of glucocorticoids. Verapamil did not affect on this response. Conclusion: These findings indicate that acute restraint stress impair retrieval of long-term memory, and provide evidence for the existence of an interaction between stress and L-type voltage calcium channels on this process. http://www.koomeshjournal.ir/browse.php?a_code=A-10-4-82&slc_lang=en&sid=1&ftxt=1Restraint stressVerapamilMemory retrievalVoltage-calcium sensitive channels |
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DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
A. Rashidy-Pour A.A. Taherian A.A. Vafaei H. Miladi-Gorji H. Sadeghi Y. Fathollahi A.R. Bandehgi |
spellingShingle |
A. Rashidy-Pour A.A. Taherian A.A. Vafaei H. Miladi-Gorji H. Sadeghi Y. Fathollahi A.R. Bandehgi Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān Restraint stress Verapamil Memory retrieval Voltage-calcium sensitive channels |
author_facet |
A. Rashidy-Pour A.A. Taherian A.A. Vafaei H. Miladi-Gorji H. Sadeghi Y. Fathollahi A.R. Bandehgi |
author_sort |
A. Rashidy-Pour |
title |
Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
title_short |
Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
title_full |
Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
title_fullStr |
Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
title_full_unstemmed |
Verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
title_sort |
verapamil enhances the impairing effects of stress on retrieval of long-term memory in rats |
publisher |
Semnan Univeristy of Medical Sciences |
series |
Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān |
issn |
1608-7046 |
publishDate |
2006-11-01 |
description |
Introduction: This study investigated an interaction between acute restraint stress and verapamil, as a blocker of L-type voltage sensitive channels on retrieval of long-term memory. Materials and Methods: Young adult male rats were trained in one trial inhibitory avoidance task (1mA, 1.5s footshock). On retention test given 48 hr after training, the latency to re-enter dark compartment and time spent in light chamber of the apparatus were recorded. Thirty min before retention test, the rats were exposed to a 10 min of restraint stress in a Plexiglass with or without prior treatment of verapamil (5, 10, 20 mg/kg). Results: The results showed verapamil pretreatment enhanced the impairing effect of stress on memory retrieval. The applied stress increased circulating corticosterone levels as assessed immediately after the retention test, indicating that stress–induced impairment of memory retrieval is mediated, in part, by increased plasma levels of glucocorticoids. Verapamil did not affect on this response. Conclusion: These findings indicate that acute restraint stress impair retrieval of long-term memory, and provide evidence for the existence of an interaction between stress and L-type voltage calcium channels on this process. |
topic |
Restraint stress Verapamil Memory retrieval Voltage-calcium sensitive channels |
url |
http://www.koomeshjournal.ir/browse.php?a_code=A-10-4-82&slc_lang=en&sid=1&ftxt=1 |
work_keys_str_mv |
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