Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients
Objective: There is few data regarding the correlation between serum Vitamin D level and unfavorable intensive care unit (ICU) outcome in postsurgical patients. In this study, correlation between serum 25(OH)D level and length of ICU stay and in-hospital mortality has been evaluated in critically il...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
Series: | Journal of Research in Pharmacy Practice |
Subjects: | |
Online Access: | http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=193;epage=198;aulast=Alizadeh |
id |
doaj-1c887bc826ed40708b8b8388df4922ae |
---|---|
record_format |
Article |
spelling |
doaj-1c887bc826ed40708b8b8388df4922ae2020-11-25T00:56:42ZengWolters Kluwer Medknow PublicationsJournal of Research in Pharmacy Practice2319-96442279-042X2015-01-014419319810.4103/2279-042X.167051Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patientsNafiseh AlizadehHossein KhaliliMostafa MohammadiAlireza AbdollahiObjective: There is few data regarding the correlation between serum Vitamin D level and unfavorable intensive care unit (ICU) outcome in postsurgical patients. In this study, correlation between serum 25(OH)D level and length of ICU stay and in-hospital mortality has been evaluated in critically ill surgical patients. Methods: Serum 25(OH)D has been evaluated in 70 surgical, critically ill patients. Demographic, laboratory, and clinical data of the patients were collected. Correlation between serum 25(OH) D level and duration of ICU stay and hospital mortality was evaluated using two-factor analysis of covariance. Multivariable Cox-regression analysis was used for adjusting the effect of season of blood sampling and type of surgery on the main variables. For all the analyses, P values less than or equal to 0.05 were considered as statistically significant. Findings: Serum 25(OH)D deficiency was identified in 52 (74.3%) of the patients. Patients with serum Vitamin D levels < 30 ng/ml had longer length of ICU stay than those with serum Vitamin D levels ≥ 30 ng/ml (7.8 ± 5.1 vs. 4.05 ± 2.12 days, P = 0.003). Although hospital mortality was more common in Vitamin D deficient patients than sufficient ones (25% in deficient group versus 22.2% in sufficient group), there was no significant difference regarding hospital mortality rate between the groups. Conclusion: Statistically significant association was found between low 25(OH)D level and increased length of ICU stay in critically ill surgical patients. It could be explained by favorable effects of Vitamin D on immune system functions, reducing tissue dysfunction, and risk of organ failure and overall complications. However, there was no correlation between serum Vitamin D level and patients' in-hospital mortality. Further, well-designed prospective clinical studies with adequate sample size are needed to evaluate correlation between serum Vitamin D level and mortality in critically ill patients.http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=193;epage=198;aulast=AlizadehCritically ill patients; intensive care unit stay; mortality; surgical; Vitamin D |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nafiseh Alizadeh Hossein Khalili Mostafa Mohammadi Alireza Abdollahi |
spellingShingle |
Nafiseh Alizadeh Hossein Khalili Mostafa Mohammadi Alireza Abdollahi Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients Journal of Research in Pharmacy Practice Critically ill patients; intensive care unit stay; mortality; surgical; Vitamin D |
author_facet |
Nafiseh Alizadeh Hossein Khalili Mostafa Mohammadi Alireza Abdollahi |
author_sort |
Nafiseh Alizadeh |
title |
Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
title_short |
Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
title_full |
Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
title_fullStr |
Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
title_full_unstemmed |
Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
title_sort |
serum vitamin d levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Pharmacy Practice |
issn |
2319-9644 2279-042X |
publishDate |
2015-01-01 |
description |
Objective: There is few data regarding the correlation between serum Vitamin D level and unfavorable intensive care unit (ICU) outcome in postsurgical patients. In this study, correlation between serum 25(OH)D level and length of ICU stay and in-hospital mortality has been evaluated in critically ill surgical patients.
Methods: Serum 25(OH)D has been evaluated in 70 surgical, critically ill patients. Demographic, laboratory, and clinical data of the patients were collected. Correlation between serum 25(OH) D level and duration of ICU stay and hospital mortality was evaluated using two-factor analysis of covariance. Multivariable Cox-regression analysis was used for adjusting the effect of season of blood sampling and type of surgery on the main variables. For all the analyses, P values less than or equal to 0.05 were considered as statistically significant.
Findings: Serum 25(OH)D deficiency was identified in 52 (74.3%) of the patients. Patients with serum Vitamin D levels < 30 ng/ml had longer length of ICU stay than those with serum Vitamin D levels ≥ 30 ng/ml (7.8 ± 5.1 vs. 4.05 ± 2.12 days, P = 0.003). Although hospital mortality was more common in Vitamin D deficient patients than sufficient ones (25% in deficient group versus 22.2% in sufficient group), there was no significant difference regarding hospital mortality rate between the groups.
Conclusion: Statistically significant association was found between low 25(OH)D level and increased length of ICU stay in critically ill surgical patients. It could be explained by favorable effects of Vitamin D on immune system functions, reducing tissue dysfunction, and risk of organ failure and overall complications. However, there was no correlation between serum Vitamin D level and patients' in-hospital mortality. Further, well-designed prospective clinical studies with adequate sample size are needed to evaluate correlation between serum Vitamin D level and mortality in critically ill patients. |
topic |
Critically ill patients; intensive care unit stay; mortality; surgical; Vitamin D |
url |
http://www.jrpp.net/article.asp?issn=2319-9644;year=2015;volume=4;issue=4;spage=193;epage=198;aulast=Alizadeh |
work_keys_str_mv |
AT nafisehalizadeh serumvitamindlevelsatadmissionpredictthelengthofintensivecareunitstaybutnotinhospitalmortalityofcriticallyillsurgicalpatients AT hosseinkhalili serumvitamindlevelsatadmissionpredictthelengthofintensivecareunitstaybutnotinhospitalmortalityofcriticallyillsurgicalpatients AT mostafamohammadi serumvitamindlevelsatadmissionpredictthelengthofintensivecareunitstaybutnotinhospitalmortalityofcriticallyillsurgicalpatients AT alirezaabdollahi serumvitamindlevelsatadmissionpredictthelengthofintensivecareunitstaybutnotinhospitalmortalityofcriticallyillsurgicalpatients |
_version_ |
1725225905197940736 |