Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp
One of the cardinal features of neural development and adult plasticity is the contribution of activity-dependent signaling pathways. However, the interrelationships between different activity-dependent genes are not well understood. The immediate early gene neuronal-activity-regulated pentraxin (NP...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-12-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471501253X |
id |
doaj-1c90bed80b594ab28e4febc4efa09af6 |
---|---|
record_format |
Article |
spelling |
doaj-1c90bed80b594ab28e4febc4efa09af62020-11-25T01:30:15ZengElsevierCell Reports2211-12472015-12-011391747175610.1016/j.celrep.2015.10.064Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and NarpAbigail Mariga0Juliane Glaser1Leo Mathias2Desheng Xu3Meifang Xiao4Paul Worley5Ipe Ninan6Moses V. Chao7Cell and Molecular Biology Program, New York University, Langone Medical Center, New York, NY 10016, USAUnit of Genetics and Biology of Development, Institut Curie, 75005 Paris, FranceMagistère de Génétique Graduate Program, Université Paris Diderot, 75013 Paris, FranceDepartments of Neuroscience and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartments of Neuroscience and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartments of Neuroscience and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Psychiatry, New York, University, Langone Medical Center, New York, New YorkNY 10016, USADepartment of Cell Biology, Skirball Institute of Bimolecular Medicine, NYU Langone Medical Center, New York, NY 10016, USAOne of the cardinal features of neural development and adult plasticity is the contribution of activity-dependent signaling pathways. However, the interrelationships between different activity-dependent genes are not well understood. The immediate early gene neuronal-activity-regulated pentraxin (NPTX2 or Narp) encodes a protein that has been associated with excitatory synaptogenesis, AMPA receptor aggregation, and the onset of critical periods. Here, we show that Narp is a direct transcriptional target of brain-derived neurotrophic factor (BDNF), another highly regulated activity-dependent gene involved in synaptic plasticity. Unexpectedly, Narp is bidirectionally regulated by BDNF. Acute BDNF withdrawal results in downregulation of Narp, whereas transcription of Narp is greatly enhanced by BDNF. Furthermore, our results show that BDNF directly regulates Narp to mediate glutamatergic transmission and mossy fiber plasticity. Hence, Narp serves as a significant epistatic target of BDNF to regulate synaptic plasticity during periods of dynamic activity.http://www.sciencedirect.com/science/article/pii/S221112471501253X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abigail Mariga Juliane Glaser Leo Mathias Desheng Xu Meifang Xiao Paul Worley Ipe Ninan Moses V. Chao |
spellingShingle |
Abigail Mariga Juliane Glaser Leo Mathias Desheng Xu Meifang Xiao Paul Worley Ipe Ninan Moses V. Chao Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp Cell Reports |
author_facet |
Abigail Mariga Juliane Glaser Leo Mathias Desheng Xu Meifang Xiao Paul Worley Ipe Ninan Moses V. Chao |
author_sort |
Abigail Mariga |
title |
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp |
title_short |
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp |
title_full |
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp |
title_fullStr |
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp |
title_full_unstemmed |
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp |
title_sort |
definition of a bidirectional activity-dependent pathway involving bdnf and narp |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2015-12-01 |
description |
One of the cardinal features of neural development and adult plasticity is the contribution of activity-dependent signaling pathways. However, the interrelationships between different activity-dependent genes are not well understood. The immediate early gene neuronal-activity-regulated pentraxin (NPTX2 or Narp) encodes a protein that has been associated with excitatory synaptogenesis, AMPA receptor aggregation, and the onset of critical periods. Here, we show that Narp is a direct transcriptional target of brain-derived neurotrophic factor (BDNF), another highly regulated activity-dependent gene involved in synaptic plasticity. Unexpectedly, Narp is bidirectionally regulated by BDNF. Acute BDNF withdrawal results in downregulation of Narp, whereas transcription of Narp is greatly enhanced by BDNF. Furthermore, our results show that BDNF directly regulates Narp to mediate glutamatergic transmission and mossy fiber plasticity. Hence, Narp serves as a significant epistatic target of BDNF to regulate synaptic plasticity during periods of dynamic activity. |
url |
http://www.sciencedirect.com/science/article/pii/S221112471501253X |
work_keys_str_mv |
AT abigailmariga definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT julianeglaser definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT leomathias definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT deshengxu definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT meifangxiao definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT paulworley definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT ipeninan definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp AT mosesvchao definitionofabidirectionalactivitydependentpathwayinvolvingbdnfandnarp |
_version_ |
1725092520254242816 |