Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?
Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrat...
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doaj-1c965e8c796c41c9a330bf6a428fc8ff2021-01-03T00:00:12ZengMDPI AGCells2073-44092021-01-0110595910.3390/cells10010059Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?Anna Julie Peired0Maria Elena Melica1Alice Molli2Cosimo Nardi3Paola Romagnani4Laura Lasagni5Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyNephrology and Dialysis Unit, Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyKidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal regenerative responses of these progenitors can contribute to pathologic conditions. The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-like receptor 2) and leptin, are also important in this process. In this review, we summarize the plethora of molecular mechanisms directing renal progenitor responses during homeostasis and following kidney injury. Finally, we will explore how single-cell RNA sequencing could bring the characterization of renal progenitors to the next level, while knowing their molecular signature is gaining relevance in the clinic.https://www.mdpi.com/2073-4409/10/1/59renal progenitorsmolecular mechanismskidney injurysingle-cell RNA sequencingmolecular signature |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Julie Peired Maria Elena Melica Alice Molli Cosimo Nardi Paola Romagnani Laura Lasagni |
spellingShingle |
Anna Julie Peired Maria Elena Melica Alice Molli Cosimo Nardi Paola Romagnani Laura Lasagni Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? Cells renal progenitors molecular mechanisms kidney injury single-cell RNA sequencing molecular signature |
author_facet |
Anna Julie Peired Maria Elena Melica Alice Molli Cosimo Nardi Paola Romagnani Laura Lasagni |
author_sort |
Anna Julie Peired |
title |
Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? |
title_short |
Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? |
title_full |
Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? |
title_fullStr |
Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? |
title_full_unstemmed |
Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle? |
title_sort |
molecular mechanisms of renal progenitor regulation: how many pieces in the puzzle? |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-01-01 |
description |
Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal regenerative responses of these progenitors can contribute to pathologic conditions. The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-like receptor 2) and leptin, are also important in this process. In this review, we summarize the plethora of molecular mechanisms directing renal progenitor responses during homeostasis and following kidney injury. Finally, we will explore how single-cell RNA sequencing could bring the characterization of renal progenitors to the next level, while knowing their molecular signature is gaining relevance in the clinic. |
topic |
renal progenitors molecular mechanisms kidney injury single-cell RNA sequencing molecular signature |
url |
https://www.mdpi.com/2073-4409/10/1/59 |
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