Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death
Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preven...
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doaj-1c9a43d0d83e45b3af93f28c6d42a01f2020-11-24T21:34:29ZengMDPI AGNutrients2072-66432019-08-01118185210.3390/nu11081852nu11081852Selenoprotein-P Deficiency Predicts Cardiovascular Disease and DeathLutz Schomburg0Marju Orho-Melander1Joachim Struck2Andreas Bergmann3Olle Melander4Institut für Experimentelle Endokrinologie, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-13353 Berlin, GermanyDepartment of Clinical Sciences, Malmö, Lund University, SE 214 28 Malmö, SwedenSphingotec GmbH, Neuendorfstrasse 15A, D-16761 Hennigsdorf, GermanySphingotec GmbH, Neuendorfstrasse 15A, D-16761 Hennigsdorf, GermanyDepartment of Clinical Sciences, Malmö, Lund University, SE 214 28 Malmö, SwedenSelenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preventive setting. SELENOP was measured from the baseline exam in 2002−2006 of the Malmö Preventive Project, a population-based prospective cohort study, using a validated ELISA. Quintiles of SELENOP concentration were related to the risk of all-cause mortality, cardiovascular mortality, and a first cardiovascular event in 4366 subjects during a median (interquartile range) follow-up time of 9.3 (8.3−11) years using Cox proportional Hazards Model adjusting for cardiovascular risk factors. Compared to subjects in the lowest quintile of SELENOP, the risk of all three endpoints was significantly lower in quintiles 2−5. The risk (multivariate adjusted hazard ratio, 95% CI) decreased gradually with the lowest risk in quintile 4 for all-cause mortality (0.57, 0.48−0.69) (<i>p</i> < 0.001), cardiovascular mortality (0.52, 0.37−0.72) (<i>p</i> < 0.001), and first cardiovascular event (0.56, 0.44−0.71) (<i>p</i> < 0.001). The lower risk of a first cardiovascular event in quintiles 2−5 as compared to quintile 1 was significant for both coronary artery disease and stroke. We conclude that the 20% with lowest SELENOP concentrations in a North European population without history of cardiovascular disease have markedly increased risk of cardiovascular morbidity and mortality, and preventive selenium supplementation studies stratified for these subjects are warranted.https://www.mdpi.com/2072-6643/11/8/1852Selenoprotein-Pseleniumcardiovascular diseasepreventionsupplementation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lutz Schomburg Marju Orho-Melander Joachim Struck Andreas Bergmann Olle Melander |
spellingShingle |
Lutz Schomburg Marju Orho-Melander Joachim Struck Andreas Bergmann Olle Melander Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death Nutrients Selenoprotein-P selenium cardiovascular disease prevention supplementation |
author_facet |
Lutz Schomburg Marju Orho-Melander Joachim Struck Andreas Bergmann Olle Melander |
author_sort |
Lutz Schomburg |
title |
Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death |
title_short |
Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death |
title_full |
Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death |
title_fullStr |
Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death |
title_full_unstemmed |
Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death |
title_sort |
selenoprotein-p deficiency predicts cardiovascular disease and death |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-08-01 |
description |
Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preventive setting. SELENOP was measured from the baseline exam in 2002−2006 of the Malmö Preventive Project, a population-based prospective cohort study, using a validated ELISA. Quintiles of SELENOP concentration were related to the risk of all-cause mortality, cardiovascular mortality, and a first cardiovascular event in 4366 subjects during a median (interquartile range) follow-up time of 9.3 (8.3−11) years using Cox proportional Hazards Model adjusting for cardiovascular risk factors. Compared to subjects in the lowest quintile of SELENOP, the risk of all three endpoints was significantly lower in quintiles 2−5. The risk (multivariate adjusted hazard ratio, 95% CI) decreased gradually with the lowest risk in quintile 4 for all-cause mortality (0.57, 0.48−0.69) (<i>p</i> < 0.001), cardiovascular mortality (0.52, 0.37−0.72) (<i>p</i> < 0.001), and first cardiovascular event (0.56, 0.44−0.71) (<i>p</i> < 0.001). The lower risk of a first cardiovascular event in quintiles 2−5 as compared to quintile 1 was significant for both coronary artery disease and stroke. We conclude that the 20% with lowest SELENOP concentrations in a North European population without history of cardiovascular disease have markedly increased risk of cardiovascular morbidity and mortality, and preventive selenium supplementation studies stratified for these subjects are warranted. |
topic |
Selenoprotein-P selenium cardiovascular disease prevention supplementation |
url |
https://www.mdpi.com/2072-6643/11/8/1852 |
work_keys_str_mv |
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