Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease
Since discovery in 1982, carboxypeptidase E (CPE) has been shown to be involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues, and in the nervous system. This protein is produced from pro-CPE and exists in soluble and membrane forms. Membrane CPE med...
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doaj-1c9abc01e70f429887704c1b8866777e2020-11-25T01:02:32ZengBioscientificaEndocrine Connections2049-36142049-36142017-04-0164R18R3810.1530/EC-17-0020Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in diseaseLin Ji0Huan-Tong Wu1Xiao-Yan Qin2Rongfeng Lan3Department of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, ChinaBeijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, ChinaBeijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, ChinaDepartment of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, ChinaSince discovery in 1982, carboxypeptidase E (CPE) has been shown to be involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues, and in the nervous system. This protein is produced from pro-CPE and exists in soluble and membrane forms. Membrane CPE mediates the targeting of prohormones to the regulated secretory pathway, while soluble CPE acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. CPE also participates in protein internalization, vesicle transport and regulation of signaling pathways. Therefore, in two types of CPE mutant mice, Cpefat/Cpefat and Cpe knockout, loss of normal CPE leads to a lot of disorders, including diabetes, hyperproinsulinemia, low bone mineral density and deficits in learning and memory. In addition, the potential roles of CPE and ΔN-CPE, an N-terminal truncated form, in tumorigenesis and diagnosis were also addressed. Herein, we focus on dissecting the pathophysiological roles of CPE in the endocrine and nervous systems, and related diseases.http://www.endocrineconnections.com/content/6/4/R18.fullcarboxypeptidase Eexopeptidaseregulated secretory pathwaydiabetesobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Ji Huan-Tong Wu Xiao-Yan Qin Rongfeng Lan |
spellingShingle |
Lin Ji Huan-Tong Wu Xiao-Yan Qin Rongfeng Lan Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease Endocrine Connections carboxypeptidase E exopeptidase regulated secretory pathway diabetes obesity |
author_facet |
Lin Ji Huan-Tong Wu Xiao-Yan Qin Rongfeng Lan |
author_sort |
Lin Ji |
title |
Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease |
title_short |
Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease |
title_full |
Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease |
title_fullStr |
Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease |
title_full_unstemmed |
Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease |
title_sort |
dissecting carboxypeptidase e: properties, functions and pathophysiological roles in disease |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2017-04-01 |
description |
Since discovery in 1982, carboxypeptidase E (CPE) has been shown to be involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine
tissues, and in the nervous system. This protein is produced from pro-CPE and exists in soluble and membrane forms. Membrane CPE mediates the targeting of prohormones
to the regulated secretory pathway, while soluble CPE acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. CPE also participates in protein internalization, vesicle transport and regulation of signaling pathways. Therefore, in two types of CPE mutant mice, Cpefat/Cpefat and Cpe knockout, loss of normal CPE leads to a lot of disorders, including diabetes,
hyperproinsulinemia, low bone mineral density and deficits in learning and memory.
In addition, the potential roles of CPE and ΔN-CPE, an N-terminal truncated form, in tumorigenesis and diagnosis were also addressed. Herein, we focus on dissecting the pathophysiological roles of CPE in the endocrine and nervous systems, and related
diseases. |
topic |
carboxypeptidase E exopeptidase regulated secretory pathway diabetes obesity |
url |
http://www.endocrineconnections.com/content/6/4/R18.full |
work_keys_str_mv |
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