The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight
Background: There has been a growing need for colistin as a key drug for the treatment of MDR-GNB infection. Information on colistin use in Asian population is limited. Methods: A retrospective observational study was conducted to assess the efficacy and nephrotoxicity in critically ill adult patien...
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doaj-1cab30ac663343218e9648cb381630b22020-11-24T22:55:28ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-06-0135C182310.1016/j.ijid.2015.03.020The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weightNguyen Gia Binh0Kayoko Hayakawa1Dao Xuan Co2Nguyen Dang Tuan3Nguyen Hoang Anh4Nguyen Thi Hong Thuy5Doan Mai Phuong6Nguyen Thi Lien Huong7Pham Thi Phuong Thuy8Ngo Qui Chau9Pham Hong Nhung10Do Thi Hong Gam11Duong Thanh Hai12Tran Thu Huong13Le Van Anh14Nozomi Takeshita15Norio Ohmagari16Intensive Care Unit of Bach Mai Hospital, Hanoi, VietnamDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, JapanIntensive Care Unit of Bach Mai Hospital, Hanoi, VietnamIntensive Care Unit of Bach Mai Hospital, Hanoi, VietnamHanoi University of Pharmacy, Hanoi, VietnamPharmacy department of Bach Mai Hospital, Hanoi, VietnamMicrobiology Department of Bach Mai hospital, Hanoi, VietnamHanoi University of Pharmacy, Hanoi, VietnamNational Center for Global Health and Medicine - Bach Mai hospital Medical Collaboration CenterRespiratory Department, Bach Mai Hospital, Hanoi, VietnamMicrobiology Department of Bach Mai hospital, Hanoi, VietnamPharmacy department of Bach Mai Hospital, Hanoi, VietnamPharmacy department of Bach Mai Hospital, Hanoi, VietnamPharmacy department of Bach Mai Hospital, Hanoi, VietnamPharmacy department of Bach Mai Hospital, Hanoi, VietnamDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, JapanDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, JapanBackground: There has been a growing need for colistin as a key drug for the treatment of MDR-GNB infection. Information on colistin use in Asian population is limited. Methods: A retrospective observational study was conducted to assess the efficacy and nephrotoxicity in critically ill adult patients who received intravenous colistin for MDR-GNB infection in the intensive care unit (ICU) at Bach Mai Hospital in Hanoi, Vietnam. Colistin was administered according to the dosing guideline that was based on pharmacokinetic, pharmacodynamic and toxicodynamic principles, adjusted by body weight and creatinine clearance. Results: Twenty-eight eligible patients were included. The mean patient age was 60 ± 20.4 years. The mean body weight was 53 ± 8.6 kg. The mean daily dose of colistin was 4.1 ± 1.6 MIU, and the mean cumulative dose of colistin was 48.2 ± 22.8 MIU. Colistin therapies were classified as clinically effective in 19 (67.9%) cases. Six (21.4%) patients developed nephrotoxicity during the study period according to RIFLE criteria. Conclusion: A personalized dosing protocol of colistin was effective, with low nephrotoxicity, among critically ill Vietnamese patients with low body weight. Further studies are warranted for assessing the efficacy and toxicity in a larger cohort.http://www.sciencedirect.com/science/article/pii/S1201971215000818ColistinHospital acquired infectionICUNephrotoxicityAsiaLower body weight |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nguyen Gia Binh Kayoko Hayakawa Dao Xuan Co Nguyen Dang Tuan Nguyen Hoang Anh Nguyen Thi Hong Thuy Doan Mai Phuong Nguyen Thi Lien Huong Pham Thi Phuong Thuy Ngo Qui Chau Pham Hong Nhung Do Thi Hong Gam Duong Thanh Hai Tran Thu Huong Le Van Anh Nozomi Takeshita Norio Ohmagari |
spellingShingle |
Nguyen Gia Binh Kayoko Hayakawa Dao Xuan Co Nguyen Dang Tuan Nguyen Hoang Anh Nguyen Thi Hong Thuy Doan Mai Phuong Nguyen Thi Lien Huong Pham Thi Phuong Thuy Ngo Qui Chau Pham Hong Nhung Do Thi Hong Gam Duong Thanh Hai Tran Thu Huong Le Van Anh Nozomi Takeshita Norio Ohmagari The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight International Journal of Infectious Diseases Colistin Hospital acquired infection ICU Nephrotoxicity Asia Lower body weight |
author_facet |
Nguyen Gia Binh Kayoko Hayakawa Dao Xuan Co Nguyen Dang Tuan Nguyen Hoang Anh Nguyen Thi Hong Thuy Doan Mai Phuong Nguyen Thi Lien Huong Pham Thi Phuong Thuy Ngo Qui Chau Pham Hong Nhung Do Thi Hong Gam Duong Thanh Hai Tran Thu Huong Le Van Anh Nozomi Takeshita Norio Ohmagari |
author_sort |
Nguyen Gia Binh |
title |
The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight |
title_short |
The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight |
title_full |
The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight |
title_fullStr |
The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight |
title_full_unstemmed |
The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight |
title_sort |
efficacy and nephrotoxicity associated with colistin use in an intensive care unit in vietnam: use of colistin in a population of lower body weight |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2015-06-01 |
description |
Background: There has been a growing need for colistin as a key drug for the treatment of MDR-GNB infection. Information on colistin use in Asian population is limited.
Methods: A retrospective observational study was conducted to assess the efficacy and nephrotoxicity in critically ill adult patients who received intravenous colistin for MDR-GNB infection in the intensive care unit (ICU) at Bach Mai Hospital in Hanoi, Vietnam. Colistin was administered according to the dosing guideline that was based on pharmacokinetic, pharmacodynamic and toxicodynamic principles, adjusted by body weight and creatinine clearance.
Results: Twenty-eight eligible patients were included. The mean patient age was 60 ± 20.4 years. The mean body weight was 53 ± 8.6 kg. The mean daily dose of colistin was 4.1 ± 1.6 MIU, and the mean cumulative dose of colistin was 48.2 ± 22.8 MIU. Colistin therapies were classified as clinically effective in 19 (67.9%) cases. Six (21.4%) patients developed nephrotoxicity during the study period according to RIFLE criteria.
Conclusion: A personalized dosing protocol of colistin was effective, with low nephrotoxicity, among critically ill Vietnamese patients with low body weight. Further studies are warranted for assessing the efficacy and toxicity in a larger cohort. |
topic |
Colistin Hospital acquired infection ICU Nephrotoxicity Asia Lower body weight |
url |
http://www.sciencedirect.com/science/article/pii/S1201971215000818 |
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