Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications
Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability...
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2021-02-01
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doaj-1cac0526d9804820b0d9069be201e2e02021-02-18T17:19:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-02-01910.3389/fbioe.2021.650598650598Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and ApplicationsPeipei Feng0Yang Luo1Chunhai Ke2Haofeng Qiu3Wei Wang4Yabin Zhu5Ruixia Hou6Long Xu7Songze Wu8School of Medicine, Ningbo University, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaLihuili Hospital, Affiliated Hospital of Ningbo University, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaSchool of Medicine, Ningbo University, Ningbo, ChinaSchool of Materials Science and Chemical Engineering, Ningbo University, Ningbo, ChinaNingbo Baoting Biotechnology Co., Ltd., Ningbo, ChinaSkin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels.https://www.frontiersin.org/articles/10.3389/fbioe.2021.650598/fullchitosanfunctional materialshydrogelswound repairmechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peipei Feng Yang Luo Chunhai Ke Haofeng Qiu Wei Wang Yabin Zhu Ruixia Hou Long Xu Songze Wu |
spellingShingle |
Peipei Feng Yang Luo Chunhai Ke Haofeng Qiu Wei Wang Yabin Zhu Ruixia Hou Long Xu Songze Wu Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications Frontiers in Bioengineering and Biotechnology chitosan functional materials hydrogels wound repair mechanisms |
author_facet |
Peipei Feng Yang Luo Chunhai Ke Haofeng Qiu Wei Wang Yabin Zhu Ruixia Hou Long Xu Songze Wu |
author_sort |
Peipei Feng |
title |
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications |
title_short |
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications |
title_full |
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications |
title_fullStr |
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications |
title_full_unstemmed |
Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications |
title_sort |
chitosan-based functional materials for skin wound repair: mechanisms and applications |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2021-02-01 |
description |
Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels. |
topic |
chitosan functional materials hydrogels wound repair mechanisms |
url |
https://www.frontiersin.org/articles/10.3389/fbioe.2021.650598/full |
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