Sarcopenia and Menopause: The Role of Estradiol
During aging and menopausal transition in women, a progressive muscle degeneration (i.e. decrease in quality and muscle function) occurs. This muscle dysfunction, caused by decreased proliferation of muscle satellite cells, increased levels of inflammatory markers, and altered levels of sex hormones...
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doaj-1caee911beec4fce9419207897250ac92021-05-19T05:54:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-05-011210.3389/fendo.2021.682012682012Sarcopenia and Menopause: The Role of EstradiolAnnalisa Geraci0Riccardo Calvani1Riccardo Calvani2Evelyn Ferri3Emanuele Marzetti4Emanuele Marzetti5Beatrice Arosio6Beatrice Arosio7Matteo Cesari8Matteo Cesari9Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenGeriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyInstitute of Internal Medicine and Geriatrics, Università Cattolica del Sacro Cuore, Rome, ItalyGeriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, Milan, ItalyGeriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, ItalyDuring aging and menopausal transition in women, a progressive muscle degeneration (i.e. decrease in quality and muscle function) occurs. This muscle dysfunction, caused by decreased proliferation of muscle satellite cells, increased levels of inflammatory markers, and altered levels of sex hormones, exposes women to a raised incidence of sarcopenia. In this regard, hormonal balance and, in particular, estradiol, seems to be essential in skeletal muscle function. The role of the estradiol on satellite cells and the release of inflammatory cytokines in menopausal women are reviewed. In particular, estradiol has a beneficial effect on the skeletal muscle by stimulating satellite cell proliferation. Skeletal muscle can respond to estrogenic hormonal control due to the presence of specific receptors for estradiol at the level of muscle fibers. Additionally, estradiol can limit inflammatory stress damage on skeletal muscle. In this review, we primarily focused on the role of estradiol in sarcopenia and on the possibility of using Estradiol Replacement Therapy, which combined with nutritional and physical activity programs, can counteract this condition representing a valid tool to treat sarcopenia in women.https://www.frontiersin.org/articles/10.3389/fendo.2021.682012/fullagingendocrinologyhormonesmenopausemuscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Annalisa Geraci Riccardo Calvani Riccardo Calvani Evelyn Ferri Emanuele Marzetti Emanuele Marzetti Beatrice Arosio Beatrice Arosio Matteo Cesari Matteo Cesari |
spellingShingle |
Annalisa Geraci Riccardo Calvani Riccardo Calvani Evelyn Ferri Emanuele Marzetti Emanuele Marzetti Beatrice Arosio Beatrice Arosio Matteo Cesari Matteo Cesari Sarcopenia and Menopause: The Role of Estradiol Frontiers in Endocrinology aging endocrinology hormones menopause muscle |
author_facet |
Annalisa Geraci Riccardo Calvani Riccardo Calvani Evelyn Ferri Emanuele Marzetti Emanuele Marzetti Beatrice Arosio Beatrice Arosio Matteo Cesari Matteo Cesari |
author_sort |
Annalisa Geraci |
title |
Sarcopenia and Menopause: The Role of Estradiol |
title_short |
Sarcopenia and Menopause: The Role of Estradiol |
title_full |
Sarcopenia and Menopause: The Role of Estradiol |
title_fullStr |
Sarcopenia and Menopause: The Role of Estradiol |
title_full_unstemmed |
Sarcopenia and Menopause: The Role of Estradiol |
title_sort |
sarcopenia and menopause: the role of estradiol |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-05-01 |
description |
During aging and menopausal transition in women, a progressive muscle degeneration (i.e. decrease in quality and muscle function) occurs. This muscle dysfunction, caused by decreased proliferation of muscle satellite cells, increased levels of inflammatory markers, and altered levels of sex hormones, exposes women to a raised incidence of sarcopenia. In this regard, hormonal balance and, in particular, estradiol, seems to be essential in skeletal muscle function. The role of the estradiol on satellite cells and the release of inflammatory cytokines in menopausal women are reviewed. In particular, estradiol has a beneficial effect on the skeletal muscle by stimulating satellite cell proliferation. Skeletal muscle can respond to estrogenic hormonal control due to the presence of specific receptors for estradiol at the level of muscle fibers. Additionally, estradiol can limit inflammatory stress damage on skeletal muscle. In this review, we primarily focused on the role of estradiol in sarcopenia and on the possibility of using Estradiol Replacement Therapy, which combined with nutritional and physical activity programs, can counteract this condition representing a valid tool to treat sarcopenia in women. |
topic |
aging endocrinology hormones menopause muscle |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.682012/full |
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