Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in...
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2017-01-01
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Online Access: | http://dx.doi.org/10.1155/2017/5241012 |
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doaj-1cb216f7bf49424aa9f7f4d08babba342020-11-24T23:51:02ZengHindawi LimitedDisease Markers0278-02401875-86302017-01-01201710.1155/2017/52410125241012Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis PatientsAlexandru Caraba0Viorica Crişan1Ioan Romoşan2Ioana Mozoş3Marius Murariu4Department of Internal Medicine, Division of Rheumatology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, RomaniaDivision of Rheumatology, Timişoara, RomaniaDepartment of Internal Medicine, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, RomaniaDepartment of Pathophysiology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babeş”, Timişoara, RomaniaCardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.http://dx.doi.org/10.1155/2017/5241012 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandru Caraba Viorica Crişan Ioan Romoşan Ioana Mozoş Marius Murariu |
spellingShingle |
Alexandru Caraba Viorica Crişan Ioan Romoşan Ioana Mozoş Marius Murariu Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients Disease Markers |
author_facet |
Alexandru Caraba Viorica Crişan Ioan Romoşan Ioana Mozoş Marius Murariu |
author_sort |
Alexandru Caraba |
title |
Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients |
title_short |
Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients |
title_full |
Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients |
title_fullStr |
Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients |
title_full_unstemmed |
Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients |
title_sort |
vitamin d status, disease activity, and endothelial dysfunction in early rheumatoid arthritis patients |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2017-01-01 |
description |
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction. |
url |
http://dx.doi.org/10.1155/2017/5241012 |
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