The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro
Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protect...
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Online Access: | http://dx.doi.org/10.1155/2016/2918796 |
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doaj-1cb70606c4b64ae2bfeda28f46c653f52020-11-24T22:12:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882016-01-01201610.1155/2016/29187962918796The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In VitroHao Huang0Linfu Li1Weimei Shi2Hai Liu3Jianqiong Yang4Xiaoliang Yuan5Longhuo Wu6College of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaDepartment of Clinical Research Center, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaNobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. These events may be underpinned by modulation of signaling cascades, including PKA/ERK/MEK/CREB, NF-κB, MAPK, Ca2+/CaMKII, PI3K/Akt1/2, HIF-1α, and TGFβ signaling pathways. The metabolites may exhibit stronger beneficial effects than NOB on diseases pathogenesis. The biological activities of NOB have been clarified on many systems. This review aims to discuss the pharmacological effects of NOB with specific mechanisms of actions. NOB may become a promising candidate for potential drug development. However, further investigations of NOB on specific intracellular targets and clinical trials are still needed, especially for in vivo medical applications.http://dx.doi.org/10.1155/2016/2918796 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao Huang Linfu Li Weimei Shi Hai Liu Jianqiong Yang Xiaoliang Yuan Longhuo Wu |
spellingShingle |
Hao Huang Linfu Li Weimei Shi Hai Liu Jianqiong Yang Xiaoliang Yuan Longhuo Wu The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro Evidence-Based Complementary and Alternative Medicine |
author_facet |
Hao Huang Linfu Li Weimei Shi Hai Liu Jianqiong Yang Xiaoliang Yuan Longhuo Wu |
author_sort |
Hao Huang |
title |
The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
title_short |
The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
title_full |
The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
title_fullStr |
The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
title_full_unstemmed |
The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
title_sort |
multifunctional effects of nobiletin and its metabolites in vivo and in vitro |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2016-01-01 |
description |
Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. These events may be underpinned by modulation of signaling cascades, including PKA/ERK/MEK/CREB, NF-κB, MAPK, Ca2+/CaMKII, PI3K/Akt1/2, HIF-1α, and TGFβ signaling pathways. The metabolites may exhibit stronger beneficial effects than NOB on diseases pathogenesis. The biological activities of NOB have been clarified on many systems. This review aims to discuss the pharmacological effects of NOB with specific mechanisms of actions. NOB may become a promising candidate for potential drug development. However, further investigations of NOB on specific intracellular targets and clinical trials are still needed, especially for in vivo medical applications. |
url |
http://dx.doi.org/10.1155/2016/2918796 |
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