Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells

Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells

<p>Abstract</p> <p>In mammalian cells, nucleolar localization of influenza A NS1 requires the presence of a C-terminal nucleolar localization signal. This nucleolar localization signal is present only in certain strains of influenza A viruses. Therefore, only certain NS1 accumulate...

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Main Authors: Mazel-Sanchez Beryl, Volmer Romain, Volmer Christelle, Soubies Sébastien M, Guérin Jean-Luc
Format: Article
Language:English
Published: BMC 2010-03-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/7/1/63
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spelling doaj-1cb874df2d1c475da085b18d2edccd872020-11-24T21:37:56ZengBMCVirology Journal1743-422X2010-03-01716310.1186/1743-422X-7-63Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cellsMazel-Sanchez BerylVolmer RomainVolmer ChristelleSoubies Sébastien MGuérin Jean-Luc<p>Abstract</p> <p>In mammalian cells, nucleolar localization of influenza A NS1 requires the presence of a C-terminal nucleolar localization signal. This nucleolar localization signal is present only in certain strains of influenza A viruses. Therefore, only certain NS1 accumulate in the nucleolus of mammalian cells. In contrast, we show that all NS1 tested in this study accumulated in the nucleolus of avian cells even in the absence of the above described C-terminal nucleolar localization signal. Thus, nucleolar localization of NS1 in avian cells appears to rely on a different nucleolar localization signal that is more conserved among influenza virus strains.</p> http://www.virologyj.com/content/7/1/63
collection DOAJ
language English
format Article
sources DOAJ
author Mazel-Sanchez Beryl
Volmer Romain
Volmer Christelle
Soubies Sébastien M
Guérin Jean-Luc
spellingShingle Mazel-Sanchez Beryl
Volmer Romain
Volmer Christelle
Soubies Sébastien M
Guérin Jean-Luc
Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
Virology Journal
author_facet Mazel-Sanchez Beryl
Volmer Romain
Volmer Christelle
Soubies Sébastien M
Guérin Jean-Luc
author_sort Mazel-Sanchez Beryl
title Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
title_short Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
title_full Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
title_fullStr Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
title_full_unstemmed Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
title_sort nucleolar localization of influenza a ns1: striking differences between mammalian and avian cells
publisher BMC
series Virology Journal
issn 1743-422X
publishDate 2010-03-01
description <p>Abstract</p> <p>In mammalian cells, nucleolar localization of influenza A NS1 requires the presence of a C-terminal nucleolar localization signal. This nucleolar localization signal is present only in certain strains of influenza A viruses. Therefore, only certain NS1 accumulate in the nucleolus of mammalian cells. In contrast, we show that all NS1 tested in this study accumulated in the nucleolus of avian cells even in the absence of the above described C-terminal nucleolar localization signal. Thus, nucleolar localization of NS1 in avian cells appears to rely on a different nucleolar localization signal that is more conserved among influenza virus strains.</p>
url http://www.virologyj.com/content/7/1/63
work_keys_str_mv AT mazelsanchezberyl nucleolarlocalizationofinfluenzaans1strikingdifferencesbetweenmammalianandaviancells
AT volmerromain nucleolarlocalizationofinfluenzaans1strikingdifferencesbetweenmammalianandaviancells
AT volmerchristelle nucleolarlocalizationofinfluenzaans1strikingdifferencesbetweenmammalianandaviancells
AT soubiessebastienm nucleolarlocalizationofinfluenzaans1strikingdifferencesbetweenmammalianandaviancells
AT guerinjeanluc nucleolarlocalizationofinfluenzaans1strikingdifferencesbetweenmammalianandaviancells
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