Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling
Abstract Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the role of Rho kinase (ROCK) in aldosterone/MR signaling and vascular dysfunction in a model of diabetes. Diabet...
Main Authors: | Aurelie Nguyen Dinh Cat, Glaucia E. Callera, Malou Friederich-Persson, Ana Sanchez, Maria Gabriela Dulak-Lis, Sofia Tsiropoulou, Augusto C. Montezano, Ying He, Ana M. Briones, Frederic Jaisser, Rhian M. Touyz |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-02-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-21087-5 |
Similar Items
-
Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue
by: Clara Lefranc, et al.
Published: (2021-03-01) -
Role Of Hyperglycemia And Aldosterone On Renal ACE2 AND Albuminuria In db/db Mice
by: Chodavarapu, Harshita
Published: (2011) -
Impaired Corpus Cavernosum Relaxation Is Accompanied by Increased Oxidative Stress and Up-Regulation of the Rho-Kinase Pathway in Diabetic (Db/Db) Mice.
by: Fernanda B M Priviero, et al.
Published: (2016-01-01) -
Antidiabetic and Antiobesity Effects of Artemether in db/db Mice
by: Yu Guo, et al.
Published: (2018-01-01) -
DB 2020: Analyzing and Forecasting DB Market Trends
Published: (2014)