Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, h...

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Bibliographic Details
Main Authors: Jennifer L Mamrosh, Jae Man Lee, Martin Wagner, Peter J Stambrook, Richard J Whitby, Richard N Sifers, San-Pin Wu, Ming-Jer Tsai, Francesco J DeMayo, David D Moore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
ER stress
nuclear receptor
liver metabolism
Online Access:https://elifesciences.org/articles/01694

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