P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients
Background/Aims. Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study. Methods. 72 predialysis patients were enrolled fro...
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Online Access: | http://dx.doi.org/10.1155/2014/526932 |
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doaj-1cc64e4b93374dda83786843a7aeb5292020-11-25T02:21:33ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/526932526932P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD PatientsCheng-Jui Lin0Chi-Feng Pan1Chih-Kuang Chuang2Fang-Ju Sun3Duen-Jen Wang4Han-Hsiang Chen5Hsuan-Liang Liu6Chih-Jen Wu7Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, 92 Chung San North Road, 10449 Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, 92 Chung San North Road, 10449 Taipei, TaiwanDepartment of Laboratory Medicine, Mackay Memorial Hospital, 10449 Taipei, TaiwanDepartment of Medical Research, Mackay Memorial Hospital, 10449 Taipei, TaiwanCollege of Medicine, Fu-Jen Catholic University, 24205 New Taipei City, TaiwanDivision of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, 92 Chung San North Road, 10449 Taipei, TaiwanDepartment of Laboratory Medicine, Mackay Memorial Hospital, 10449 Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, 92 Chung San North Road, 10449 Taipei, TaiwanBackground/Aims. Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study. Methods. 72 predialysis patients were enrolled from a single medical center. Serum biochemistry data and PCS were measured. The clinical outcomes including cardiovascular event, all-cause mortality, and dialysis event were recorded during a 3-year follow-up. Results. After adjusting other independent variables, multivariate Cox regression analysis showed age (HR: 1.12, P=0.01), cardiovascular disease history (HR: 6.28, P=0.02), and PCS (HR: 1.12, P=0.02) were independently associated with cardiovascular event; age (HR: 0.91, P<0.01), serum albumin (HR: 0.03, P<0.01), and PCS level (HR: 1.17, P<0.01) reached significant correlation with dialysis event. Kaplan-Meier analysis revealed that patients with higher serum p-cresyl sulfate (>6 mg/L) were significantly associated with cardiovascular and dialysis event (log rank P=0.03, log rank P<0.01, resp.). Conclusion. Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis.http://dx.doi.org/10.1155/2014/526932 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Jui Lin Chi-Feng Pan Chih-Kuang Chuang Fang-Ju Sun Duen-Jen Wang Han-Hsiang Chen Hsuan-Liang Liu Chih-Jen Wu |
spellingShingle |
Cheng-Jui Lin Chi-Feng Pan Chih-Kuang Chuang Fang-Ju Sun Duen-Jen Wang Han-Hsiang Chen Hsuan-Liang Liu Chih-Jen Wu P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients BioMed Research International |
author_facet |
Cheng-Jui Lin Chi-Feng Pan Chih-Kuang Chuang Fang-Ju Sun Duen-Jen Wang Han-Hsiang Chen Hsuan-Liang Liu Chih-Jen Wu |
author_sort |
Cheng-Jui Lin |
title |
P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients |
title_short |
P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients |
title_full |
P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients |
title_fullStr |
P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients |
title_full_unstemmed |
P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients |
title_sort |
p-cresyl sulfate is a valuable predictor of clinical outcomes in pre-esrd patients |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Background/Aims. Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study. Methods. 72 predialysis patients were enrolled from a single medical center. Serum biochemistry data and PCS were measured. The clinical outcomes including cardiovascular event, all-cause mortality, and dialysis event were recorded during a 3-year follow-up. Results. After adjusting other independent variables, multivariate Cox regression analysis showed age (HR: 1.12, P=0.01), cardiovascular disease history (HR: 6.28, P=0.02), and PCS (HR: 1.12, P=0.02) were independently associated with cardiovascular event; age (HR: 0.91, P<0.01), serum albumin (HR: 0.03, P<0.01), and PCS level (HR: 1.17, P<0.01) reached significant correlation with dialysis event. Kaplan-Meier analysis revealed that patients with higher serum p-cresyl sulfate (>6 mg/L) were significantly associated with cardiovascular and dialysis event (log rank P=0.03, log rank P<0.01, resp.). Conclusion. Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis. |
url |
http://dx.doi.org/10.1155/2014/526932 |
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