Lowest observed adverse effect level of pulmonary pathological alterations due to nitrous acid exposure in guinea pigs

Lowest observed adverse effect level of pulmonary pathological alterations due to nitrous acid exposure in guinea pigs

Abstract Background We previously demonstrated that continuous exposure to nitrous acid gas (HONO) for 4 weeks, at a concentration of 3.6 parts per million (ppm), induced pulmonary emphysema-like alterations in guinea pigs. In addition, we found that HONO affected asthma symptoms, based on the measu...

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Bibliographic Details
Main Authors: Masayuki Ohyama, Hiroshi Nishimura, Kenichi Azuma, Chika Minejima, Norimichi Takenaka, Shuichi Adachi
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Environmental Health and Preventive Medicine
Subjects:
Nitrous acid
Nitrogen dioxide
Pulmonary emphysema
Alveolar mean linear intercept
Asthma
LOAEL
Online Access:http://link.springer.com/article/10.1186/s12199-020-00895-0

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http://link.springer.com/article/10.1186/s12199-020-00895-0

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