Lowest observed adverse effect level of pulmonary pathological alterations due to nitrous acid exposure in guinea pigs
Abstract Background We previously demonstrated that continuous exposure to nitrous acid gas (HONO) for 4 weeks, at a concentration of 3.6 parts per million (ppm), induced pulmonary emphysema-like alterations in guinea pigs. In addition, we found that HONO affected asthma symptoms, based on the measu...
Main Authors: | Masayuki Ohyama, Hiroshi Nishimura, Kenichi Azuma, Chika Minejima, Norimichi Takenaka, Shuichi Adachi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-09-01
|
Series: | Environmental Health and Preventive Medicine |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12199-020-00895-0 |
Similar Items
-
A proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties
by: Marek Jakubowski, et al.
Published: (2014-08-01) -
Modeling Chronic Toxicity: A Comparison of Experimental Variability With (Q)SAR/Read-Across Predictions
by: Christoph Helma, et al.
Published: (2018-04-01) -
Studies on the marine chemistry of nitrous oxide
by: Cohen, Yuval
Published: (2012) -
Nitrous acid oxidation mechanisms
by: Richards, S. N.
Published: (1987) -
Nitrous oxide improves cardiovascular, respiratory, and thermal stability during prolonged isoflurane anesthesia in juvenile guinea pigs
by: Ryan P. Sixtus, et al.
Published: (2021-02-01)