Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial.
We sought to determine whether cognitive function in stable outpatients with heart failure (HF) is affected by HF severity. A retrospective, cross-sectional analysis was performed using data from 2, 043 outpatients with systolic HF and without prior stroke enrolled in the Warfarin versus Aspirin in...
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doaj-1cd0956c78da41ab971b08683951666e2020-11-25T00:07:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11344710.1371/journal.pone.0113447Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial.Susan GrahamSiqin YeMin QianAlexandra R SanfordMarco R Di TullioRalph L SaccoDouglas L MannBruce LevinPatrick M PullicinoRonald S FreudenbergerJohn R TeerlinkJ P MohrArthur J LabovitzGregory Y H LipConrado J EstolDirk J LokPiotr PonikowskiStefan D AnkerJohn L P ThompsonShunichi HommaWARCEF InvestigatorsWe sought to determine whether cognitive function in stable outpatients with heart failure (HF) is affected by HF severity. A retrospective, cross-sectional analysis was performed using data from 2, 043 outpatients with systolic HF and without prior stroke enrolled in the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial. Multivariable regression analysis was used to assess the relationship between cognitive function measured using the Mini-Mental Status Exam (MMSE) and markers of HF severity (left ventricular ejection fraction [LVEF], New York Heart Association [NYHA] functional class, and 6-minute walk distance). The mean (SD) for the MMSE was 28.6 (2.0), with 64 (3.1%) of the 2,043 patients meeting the cut-off of MMSE <24 that indicates need for further evaluation of cognitive impairment. After adjustment for demographic and clinical covariates, 6-minute walk distance (β-coefficient 0.002, p<0.0001), but not LVEF or NYHA functional class, was independently associated with the MMSE as a continuous measure. Age, education, smoking status, body mass index, and hemoglobin level were also independently associated with the MMSE. In conclusion, six-minute walk distance, but not LVEF or NYHA functional class, was an important predictor of cognitive function in ambulatory patients with systolic heart failure.http://europepmc.org/articles/PMC4245133?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susan Graham Siqin Ye Min Qian Alexandra R Sanford Marco R Di Tullio Ralph L Sacco Douglas L Mann Bruce Levin Patrick M Pullicino Ronald S Freudenberger John R Teerlink J P Mohr Arthur J Labovitz Gregory Y H Lip Conrado J Estol Dirk J Lok Piotr Ponikowski Stefan D Anker John L P Thompson Shunichi Homma WARCEF Investigators |
spellingShingle |
Susan Graham Siqin Ye Min Qian Alexandra R Sanford Marco R Di Tullio Ralph L Sacco Douglas L Mann Bruce Levin Patrick M Pullicino Ronald S Freudenberger John R Teerlink J P Mohr Arthur J Labovitz Gregory Y H Lip Conrado J Estol Dirk J Lok Piotr Ponikowski Stefan D Anker John L P Thompson Shunichi Homma WARCEF Investigators Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. PLoS ONE |
author_facet |
Susan Graham Siqin Ye Min Qian Alexandra R Sanford Marco R Di Tullio Ralph L Sacco Douglas L Mann Bruce Levin Patrick M Pullicino Ronald S Freudenberger John R Teerlink J P Mohr Arthur J Labovitz Gregory Y H Lip Conrado J Estol Dirk J Lok Piotr Ponikowski Stefan D Anker John L P Thompson Shunichi Homma WARCEF Investigators |
author_sort |
Susan Graham |
title |
Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. |
title_short |
Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. |
title_full |
Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. |
title_fullStr |
Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. |
title_full_unstemmed |
Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial. |
title_sort |
cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (warcef) trial. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
We sought to determine whether cognitive function in stable outpatients with heart failure (HF) is affected by HF severity. A retrospective, cross-sectional analysis was performed using data from 2, 043 outpatients with systolic HF and without prior stroke enrolled in the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial. Multivariable regression analysis was used to assess the relationship between cognitive function measured using the Mini-Mental Status Exam (MMSE) and markers of HF severity (left ventricular ejection fraction [LVEF], New York Heart Association [NYHA] functional class, and 6-minute walk distance). The mean (SD) for the MMSE was 28.6 (2.0), with 64 (3.1%) of the 2,043 patients meeting the cut-off of MMSE <24 that indicates need for further evaluation of cognitive impairment. After adjustment for demographic and clinical covariates, 6-minute walk distance (β-coefficient 0.002, p<0.0001), but not LVEF or NYHA functional class, was independently associated with the MMSE as a continuous measure. Age, education, smoking status, body mass index, and hemoglobin level were also independently associated with the MMSE. In conclusion, six-minute walk distance, but not LVEF or NYHA functional class, was an important predictor of cognitive function in ambulatory patients with systolic heart failure. |
url |
http://europepmc.org/articles/PMC4245133?pdf=render |
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