NM23-H1: a Metastasis-Associated Gene
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma...
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doaj-1cd66dd672c84a9bac05bfc3b01e2c022020-11-24T23:56:38ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592006-06-0145210711310.1016/S1028-4559(09)60206-0NM23-H1: a Metastasis-Associated GeneYi-Torng Tee0Gin-Den Chen1Long-Yau Lin2Jiunn-Liang Ko3Po-Hui Wang4Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, TaiwanThe protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of nm23 gene expression are noted in the advanced stage of thyroid carcinomas and associated with significant reductions in survival for neuroblastoma and osteosarcoma patients. Although expression of nm23/NDP kinase is divergent in various malignant tumors, its reduced expression seems to be related to increased metastatic potential in most carcinoma types. However, it is hypothesized that nm23 may play a tissue-specific role, and that different regulatory mechanisms may act in different tumors. In ovarian carcinoma, nm23-H1/NDP kinase may be correlated with some clinicopathologic characteristics. In cervical cancer, nm23-H1 is probably involved in cervical carcinogenesis and correlated with some aggressive parameters. Overexpression of nm23-H1 protein may indicate poor survival for cervical cancer patients. Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. To inhibit metastatic potential, nm23-H1 is also demonstrated to co-immunoprecipitate the kinase suppressor of Ras and phosphorylate it, and therefore reduce activation of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway in response to signaling.http://www.sciencedirect.com/science/article/pii/S1028455909602060high-grade squamous intraepithelial lesionkinase suppressor of RasmetastasisNm23-H1nucleoside diphosphate kinasesquamous cell carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-Torng Tee Gin-Den Chen Long-Yau Lin Jiunn-Liang Ko Po-Hui Wang |
spellingShingle |
Yi-Torng Tee Gin-Den Chen Long-Yau Lin Jiunn-Liang Ko Po-Hui Wang NM23-H1: a Metastasis-Associated Gene Taiwanese Journal of Obstetrics & Gynecology high-grade squamous intraepithelial lesion kinase suppressor of Ras metastasis Nm23-H1 nucleoside diphosphate kinase squamous cell carcinoma |
author_facet |
Yi-Torng Tee Gin-Den Chen Long-Yau Lin Jiunn-Liang Ko Po-Hui Wang |
author_sort |
Yi-Torng Tee |
title |
NM23-H1: a Metastasis-Associated Gene |
title_short |
NM23-H1: a Metastasis-Associated Gene |
title_full |
NM23-H1: a Metastasis-Associated Gene |
title_fullStr |
NM23-H1: a Metastasis-Associated Gene |
title_full_unstemmed |
NM23-H1: a Metastasis-Associated Gene |
title_sort |
nm23-h1: a metastasis-associated gene |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2006-06-01 |
description |
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of nm23 gene expression are noted in the advanced stage of thyroid carcinomas and associated with significant reductions in survival for neuroblastoma and osteosarcoma patients. Although expression of nm23/NDP kinase is divergent in various malignant tumors, its reduced expression seems to be related to increased metastatic potential in most carcinoma types. However, it is hypothesized that nm23 may play a tissue-specific role, and that different regulatory mechanisms may act in different tumors. In ovarian carcinoma, nm23-H1/NDP kinase may be correlated with some clinicopathologic characteristics. In cervical cancer, nm23-H1 is probably involved in cervical carcinogenesis and correlated with some aggressive parameters. Overexpression of nm23-H1 protein may indicate poor survival for cervical cancer patients. Other than histidine 118 residue (amino acid sequence 118: histidine) concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine) related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. To inhibit metastatic potential, nm23-H1 is also demonstrated to co-immunoprecipitate the kinase suppressor of Ras and phosphorylate it, and therefore reduce activation of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway in response to signaling. |
topic |
high-grade squamous intraepithelial lesion kinase suppressor of Ras metastasis Nm23-H1 nucleoside diphosphate kinase squamous cell carcinoma |
url |
http://www.sciencedirect.com/science/article/pii/S1028455909602060 |
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