Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

The pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested t...

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Main Authors:	Yuan Zhang, Yanfang Zhao, Lei Zhang, Wanpeng Yu, Yu Wang, Wenguang Chang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	cellular prion protein amyloid-β oligomers receptor Alzheimer’s disease
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2019.00339/full

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spelling	doaj-1cda63dbff634ed18f0b897ce8127df62020-11-24T23:53:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-07-011310.3389/fncel.2019.00339467166Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s DiseaseYuan Zhang0Yanfang Zhao1Lei Zhang2Wanpeng Yu3Yu Wang4Wenguang Chang5Institute for Translational Medicine, Qingdao University, Qingdao, ChinaSchool for Life Science, Institute of Biomedical Research, Shandong University of Technology, Zibo, ChinaInstitute for Translational Medicine, Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, Qingdao University, Qingdao, ChinaThe pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested the possibility of an association between AD and cellular prion protein (PrPC) levels. PrPC is a high affinity receptor for oligomeric Aβ and is important for Aβ-induced neurotoxicity and thus plays a critical role in AD pathogenesis. The determination of the relationship between PrPC and AD and the characterization of PrPC binding to Aβ will facilitate the development of novel therapies for AD.https://www.frontiersin.org/article/10.3389/fncel.2019.00339/fullcellular prion proteinamyloid-βoligomersreceptorAlzheimer’s disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuan Zhang Yanfang Zhao Lei Zhang Wanpeng Yu Yu Wang Wenguang Chang
spellingShingle	Yuan Zhang Yanfang Zhao Lei Zhang Wanpeng Yu Yu Wang Wenguang Chang Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease Frontiers in Cellular Neuroscience cellular prion protein amyloid-β oligomers receptor Alzheimer’s disease
author_facet	Yuan Zhang Yanfang Zhao Lei Zhang Wanpeng Yu Yu Wang Wenguang Chang
author_sort	Yuan Zhang
title	Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
title_short	Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
title_full	Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
title_fullStr	Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
title_full_unstemmed	Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
title_sort	cellular prion protein as a receptor of toxic amyloid-β42 oligomers is important for alzheimer’s disease
publisher	Frontiers Media S.A.
series	Frontiers in Cellular Neuroscience
issn	1662-5102
publishDate	2019-07-01
description	The pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested the possibility of an association between AD and cellular prion protein (PrPC) levels. PrPC is a high affinity receptor for oligomeric Aβ and is important for Aβ-induced neurotoxicity and thus plays a critical role in AD pathogenesis. The determination of the relationship between PrPC and AD and the characterization of PrPC binding to Aβ will facilitate the development of novel therapies for AD.
topic	cellular prion protein amyloid-β oligomers receptor Alzheimer’s disease
url	https://www.frontiersin.org/article/10.3389/fncel.2019.00339/full
work_keys_str_mv	AT yuanzhang cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease AT yanfangzhao cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease AT leizhang cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease AT wanpengyu cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease AT yuwang cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease AT wenguangchang cellularprionproteinasareceptoroftoxicamyloidb42oligomersisimportantforalzheimersdisease
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Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

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