Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors

Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual developme...

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Main Author:	Hidemi Rikiishi
Format:	Article
Language:	English
Published:	MDPI AG 2010-11-01
Series:	Cancers
Subjects:	pancreatic cancer autophagy apoptosis epigenetics histone deacetylase ER stress
Online Access:	http://www.mdpi.com/2072-6694/2/4/2026/

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spelling	doaj-1cdcb8ceae0a4564837672c15383d9222020-11-24T23:57:21ZengMDPI AGCancers2072-66942010-11-01242026204310.3390/cancers2042026Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase InhibitorsHidemi RikiishiPancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer. http://www.mdpi.com/2072-6694/2/4/2026/pancreatic cancerautophagyapoptosisepigeneticshistone deacetylaseER stress
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hidemi Rikiishi
spellingShingle	Hidemi Rikiishi Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors Cancers pancreatic cancer autophagy apoptosis epigenetics histone deacetylase ER stress
author_facet	Hidemi Rikiishi
author_sort	Hidemi Rikiishi
title	Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
title_short	Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
title_full	Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
title_fullStr	Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
title_full_unstemmed	Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
title_sort	possible role of autophagy in the treatment of pancreatic cancer with histone deacetylase inhibitors
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2010-11-01
description	Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer.
topic	pancreatic cancer autophagy apoptosis epigenetics histone deacetylase ER stress
url	http://www.mdpi.com/2072-6694/2/4/2026/
work_keys_str_mv	AT hidemirikiishi possibleroleofautophagyinthetreatmentofpancreaticcancerwithhistonedeacetylaseinhibitors
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Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors

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