Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials
Addition of bioactive materials such as Titanium oxide (TiO2), and incorporation of bio inert ceramic such as alumina (Al2O3), into polyetheretherketone (PEEK) has been adopted as an effective approach to improve bone-implant interfaces. In this paper, hot pressing technique has been adopted as a p...
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Al-Khwarizmi College of Engineering – University of Baghdad
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Online Access: | http://alkej.uobaghdad.edu.iq/index.php/alkej/article/view/99 |
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doaj-1cedf79b156144e29512cdebeeca44c12020-11-25T02:06:58Zeng Al-Khwarizmi College of Engineering – University of BaghdadAl-Khawarizmi Engineering Journal1818-11712312-07892018-09-0114310.22153/kej.2018.03.004Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute BiomaterialsJenan S. Kashan0Wisam K. Hamdan1Baha Fakhri2Department of Biomedical Engineering/ University of Technology/Baghdad/ IraqDepartment of Biomedical Engineering/ University of Technology/Baghdad/ IraqCollege of Veterinary Medicine/ University of Baghdad/ Baghdad/ Iraq Addition of bioactive materials such as Titanium oxide (TiO2), and incorporation of bio inert ceramic such as alumina (Al2O3), into polyetheretherketone (PEEK) has been adopted as an effective approach to improve bone-implant interfaces. In this paper, hot pressing technique has been adopted as a production method. This technique gave a homogenous distribution of the additive materials in the proposed composite biomaterial. Different compositions and compounding temperatures have been applied to all samples. Mechanical properties and animal model have been studied in all different production conditions. The results of these new TiO2/Al2O3/PEEK biocomposites with different compositions were promising, mechanical properties within the range of human cortical bone, suitable for load bearing applications. At the same time, in vivo test shows no inflammation reaction with implanted samples. Sustained viability in contact with the sample over seven-day period, showed evidence of excellent biocompatibility in injured rejoins. http://alkej.uobaghdad.edu.iq/index.php/alkej/article/view/99Histology analysis, Hot pressing, Mechanical Properties, Polyetheretherketone (PEEK), TiO2/Al2O3/PEEK biocomposites. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jenan S. Kashan Wisam K. Hamdan Baha Fakhri |
spellingShingle |
Jenan S. Kashan Wisam K. Hamdan Baha Fakhri Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials Al-Khawarizmi Engineering Journal Histology analysis, Hot pressing, Mechanical Properties, Polyetheretherketone (PEEK), TiO2/Al2O3/PEEK biocomposites. |
author_facet |
Jenan S. Kashan Wisam K. Hamdan Baha Fakhri |
author_sort |
Jenan S. Kashan |
title |
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials |
title_short |
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials |
title_full |
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials |
title_fullStr |
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials |
title_full_unstemmed |
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials |
title_sort |
bone defect animal model for hybrid polymer matrix nano composite as bone substitute biomaterials |
publisher |
Al-Khwarizmi College of Engineering – University of Baghdad |
series |
Al-Khawarizmi Engineering Journal |
issn |
1818-1171 2312-0789 |
publishDate |
2018-09-01 |
description |
Addition of bioactive materials such as Titanium oxide (TiO2), and incorporation of bio inert ceramic such as alumina (Al2O3), into polyetheretherketone (PEEK) has been adopted as an effective approach to improve bone-implant interfaces. In this paper, hot pressing technique has been adopted as a production method. This technique gave a homogenous distribution of the additive materials in the proposed composite biomaterial. Different compositions and compounding temperatures have been applied to all samples. Mechanical properties and animal model have been studied in all different production conditions. The results of these new TiO2/Al2O3/PEEK biocomposites with different compositions were promising, mechanical properties within the range of human cortical bone, suitable for load bearing applications. At the same time, in vivo test shows no inflammation reaction with implanted samples. Sustained viability in contact with the sample over seven-day period, showed evidence of excellent biocompatibility in injured rejoins.
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topic |
Histology analysis, Hot pressing, Mechanical Properties, Polyetheretherketone (PEEK), TiO2/Al2O3/PEEK biocomposites. |
url |
http://alkej.uobaghdad.edu.iq/index.php/alkej/article/view/99 |
work_keys_str_mv |
AT jenanskashan bonedefectanimalmodelforhybridpolymermatrixnanocompositeasbonesubstitutebiomaterials AT wisamkhamdan bonedefectanimalmodelforhybridpolymermatrixnanocompositeasbonesubstitutebiomaterials AT bahafakhri bonedefectanimalmodelforhybridpolymermatrixnanocompositeasbonesubstitutebiomaterials |
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1724931768809684992 |