A Rare Case of Anti-Yo Antibody Associated Paraneoplastic Sensory Polyganglionopathy in a Patient with Ovarian Cancer

• Main Authors: Syed Hammad Tirmazy, Rajanee Bhana
• Format: Article
• Language: English
• Published: Shiraz University of Medical Sciences 2014-06-01
• Series: Middle East Journal of Cancer
• Subjects: Ovarian cancer; Paraneoplastic syndrome; Paraneoplastic sensory polyganglionopa- thy; Anti-yo antibodies; Paraneoplastic cerebellar degeneration
• Online Access: http://mejc.sums.ac.ir/index.php/mejc/article/view/148/139

Paraneoplastic cerebellar degeneration is a rare, fatal neuronal syndrome associatedwith ovarian, breast and lung cancers. Anti-Yo antibody mediated paraneoplasticcerebellar degeneration is known to be associated with gynecological malignancies, especially ovarian cancer. However, there are no reports of anti-Yo antibody associated predominant peripheral mixed sensory and motor neuropathy in patients with ovarian cancer. Hereby, we present a case of a 75-year-old female who predominantly developed peripheral mixed sensory and motor neuropathy after undergoing surgery and adjuvant chemotherapy for FIGO stage 3, high grade serous ovarian carcinoma. She presented approximately 11 months after completion of her chemotherapy with a history of progressive peripheral mixed sensory and motor neuropathy that affected both upper and lower limbs. There was no evidence of recurrent ovarian cancer. Since paraneoplastic peripheral neuropathy is a rare disorder, timely diagnosis and early therapeutic intervention can achieve a better outcome, although management of paraneoplastic neurological disorders still remains a challenge for clinicians.