Mouse models of epithelial ovarian cancer for preclinical studies
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic...
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Science Press, PR China
2021-03-01
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Online Access: | http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.382 |
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doaj-1cf6d5da796d4f77a53f624c0a2d21d22021-04-15T06:17:59ZengScience Press, PR ChinaZoological Research2095-81372021-03-0142215316010.24272/j.issn.2095-8137.2020.382ZR-2020-382Mouse models of epithelial ovarian cancer for preclinical studiesSergey Karakashev0Ru-Gang Zhang1Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USAImmunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USAEpithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.382epithelial ovarian cancerpatient-derived xenograftsorthotopic mouse modelsubcutaneous mouse modelintraperitoneal mouse modelsyngeneic mouse modelgenetic engineered mouse model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sergey Karakashev Ru-Gang Zhang |
spellingShingle |
Sergey Karakashev Ru-Gang Zhang Mouse models of epithelial ovarian cancer for preclinical studies Zoological Research epithelial ovarian cancer patient-derived xenografts orthotopic mouse model subcutaneous mouse model intraperitoneal mouse model syngeneic mouse model genetic engineered mouse model |
author_facet |
Sergey Karakashev Ru-Gang Zhang |
author_sort |
Sergey Karakashev |
title |
Mouse models of epithelial ovarian cancer for preclinical studies |
title_short |
Mouse models of epithelial ovarian cancer for preclinical studies |
title_full |
Mouse models of epithelial ovarian cancer for preclinical studies |
title_fullStr |
Mouse models of epithelial ovarian cancer for preclinical studies |
title_full_unstemmed |
Mouse models of epithelial ovarian cancer for preclinical studies |
title_sort |
mouse models of epithelial ovarian cancer for preclinical studies |
publisher |
Science Press, PR China |
series |
Zoological Research |
issn |
2095-8137 |
publishDate |
2021-03-01 |
description |
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations. |
topic |
epithelial ovarian cancer patient-derived xenografts orthotopic mouse model subcutaneous mouse model intraperitoneal mouse model syngeneic mouse model genetic engineered mouse model |
url |
http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.382 |
work_keys_str_mv |
AT sergeykarakashev mousemodelsofepithelialovariancancerforpreclinicalstudies AT rugangzhang mousemodelsofepithelialovariancancerforpreclinicalstudies |
_version_ |
1721526536037728256 |