A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen
Cryptotanshinone (IUPAC name: (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione), a biologically active constituent extracted from the roots and rhizomes of the plant Salvia miltiorrhiza, has been studied in depth as a medicinally active compound and shown to have efficacy...
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Elsevier
2021-05-01
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Series: | Biomedicine & Pharmacotherapy |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332221001177 |
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doaj-1cf6e2a2054141518d31419967c04c29 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huayao Li Chundi Gao Cun Liu Lijuan Liu Jing Zhuang Jing Yang Chao Zhou Fubin Feng Changgang Sun Jibiao Wu |
spellingShingle |
Huayao Li Chundi Gao Cun Liu Lijuan Liu Jing Zhuang Jing Yang Chao Zhou Fubin Feng Changgang Sun Jibiao Wu A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen Biomedicine & Pharmacotherapy Cryptotanshinone Biological activity Pharmacological Anti-cancer Anti-inflammatory |
author_facet |
Huayao Li Chundi Gao Cun Liu Lijuan Liu Jing Zhuang Jing Yang Chao Zhou Fubin Feng Changgang Sun Jibiao Wu |
author_sort |
Huayao Li |
title |
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen |
title_short |
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen |
title_full |
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen |
title_fullStr |
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen |
title_full_unstemmed |
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen |
title_sort |
review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in danshen |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-05-01 |
description |
Cryptotanshinone (IUPAC name: (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione), a biologically active constituent extracted from the roots and rhizomes of the plant Salvia miltiorrhiza, has been studied in depth as a medicinally active compound and shown to have efficacy in the treatment of numerous diseases and disorders. In this review, we describe in detail the current status of cryptotanshinone research, including findings relating to the structure, pharmacokinetics, pharmacological activity, and derivatives of this compound. Cryptotanshinoneh as a diverse range of pharmacological effects, including anti-cancer, anti-inflammatory, immune regulatory, neuroprotective, and anti-fibrosis activities. Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner to inhibit cell proliferation, migration and invasion,and induce transformation, autophagy, necrosis, and cellular immunity. The anti-inflammatory mechanisms of cryptotanshinone have been found to be associated with the TLR4-MyD88/PI3K/Nrf2 and TLR4-MyD88/NF-κB/MAPK pathways, whereasthe Hedgehog, NF-κB, and Nrf-2/HO-1 pathways are regulated by cryptotanshinone to reduce organ fibrosis, and its inhibitory effects on the PI3K/AKT-eNOS pathway have been linked to neuroprotective effects. Given the potential medicinal utility of cryptotanshinone, further research is needed to verify the efficacy and safety of this compound in clinical use, evaluate its pharmacological activity, and identify molecular targets. |
topic |
Cryptotanshinone Biological activity Pharmacological Anti-cancer Anti-inflammatory |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221001177 |
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doaj-1cf6e2a2054141518d31419967c04c292021-07-15T04:26:39ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-05-01137111332A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in DanshenHuayao Li0Chundi Gao1Cun Liu2Lijuan Liu3Jing Zhuang4Jing Yang5Chao Zhou6Fubin Feng7Changgang Sun8Jibiao Wu9College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR ChinaDepartmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR China; Department of Basic Medical Science, Qingdao University, Qingdao, 266071, PR ChinaDepartmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR China; Qingdao Academy of Chinese Medical Sciences, Shandong University of Chinese Medicine, Qingdao, 266112, Shandong, PR ChinaDepartmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR China; Departmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR ChinaDepartmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR China; Department of Basic Medical Science, Qingdao University, Qingdao, 266071, PR ChinaDepartmen of Oncology, Weifang Traditional Chinese Hospital, Weifang, 261041, Shandong, PR China; Chinese Medicine Innovation Institute, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR China; Corresponding authors at: No. 4655, University Road, University Science Park, Changqing District, Jinan City, Shandong Province, 250355, PR China.College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, PR China; Corresponding authors at: No. 4655, University Road, University Science Park, Changqing District, Jinan City, Shandong Province, 250355, PR China.Cryptotanshinone (IUPAC name: (R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione), a biologically active constituent extracted from the roots and rhizomes of the plant Salvia miltiorrhiza, has been studied in depth as a medicinally active compound and shown to have efficacy in the treatment of numerous diseases and disorders. In this review, we describe in detail the current status of cryptotanshinone research, including findings relating to the structure, pharmacokinetics, pharmacological activity, and derivatives of this compound. Cryptotanshinoneh as a diverse range of pharmacological effects, including anti-cancer, anti-inflammatory, immune regulatory, neuroprotective, and anti-fibrosis activities. Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner to inhibit cell proliferation, migration and invasion,and induce transformation, autophagy, necrosis, and cellular immunity. The anti-inflammatory mechanisms of cryptotanshinone have been found to be associated with the TLR4-MyD88/PI3K/Nrf2 and TLR4-MyD88/NF-κB/MAPK pathways, whereasthe Hedgehog, NF-κB, and Nrf-2/HO-1 pathways are regulated by cryptotanshinone to reduce organ fibrosis, and its inhibitory effects on the PI3K/AKT-eNOS pathway have been linked to neuroprotective effects. Given the potential medicinal utility of cryptotanshinone, further research is needed to verify the efficacy and safety of this compound in clinical use, evaluate its pharmacological activity, and identify molecular targets.http://www.sciencedirect.com/science/article/pii/S0753332221001177CryptotanshinoneBiological activityPharmacologicalAnti-cancerAnti-inflammatory |