Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide

Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide

The backbone cyclic and disulfide bridged sunflower trypsin inhibitor-1 (SFTI-1) peptide is a proven effective scaffold for a range of peptide therapeutics. For production at laboratory scale, solid phase peptide synthesis techniques are widely used, but these synthetic approaches are costly and env...

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Bibliographic Details
Main Authors: Mark A. Jackson, Kuok Yap, Aaron G. Poth, Edward K. Gilding, Joakim E. Swedberg, Simon Poon, Haiou Qu, Thomas Durek, Karen Harris, Marilyn A. Anderson, David J. Craik
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Plant Science
Subjects:
peptide
therapeutic
asparaginyl endopeptidase
cyclyzation
stability
biofactory
Online Access:https://www.frontiersin.org/article/10.3389/fpls.2019.00602/full

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