Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis
Background Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictor...
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Korean Society of Critical Care Medicine
2021-08-01
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Series: | Acute and Critical Care |
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Online Access: | http://www.accjournal.org/upload/pdf/acc-2021-00234.pdf |
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doaj-1d064c3eba514e0daea8f481f42a5b01 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Balaram Krishna J Hanumanthu Anika Sasidharan Nair Adarsh Katamreddy Jason S Gilbert Jee Young You Obiageli Lynda Offor Ankit Kushwaha Ankita Krishnan Marzio Napolitano Leonidas Palaidimos Joaquin Morante Seema S. Tekwani Suchita Mehta Aanchal Gupta Harmeen Goraya Mengyang Sun Robert T. Faillace Perminder Gulani |
spellingShingle |
Balaram Krishna J Hanumanthu Anika Sasidharan Nair Adarsh Katamreddy Jason S Gilbert Jee Young You Obiageli Lynda Offor Ankit Kushwaha Ankita Krishnan Marzio Napolitano Leonidas Palaidimos Joaquin Morante Seema S. Tekwani Suchita Mehta Aanchal Gupta Harmeen Goraya Mengyang Sun Robert T. Faillace Perminder Gulani Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis Acute and Critical Care cardiomyopathy mortality sepsis septic shock |
author_facet |
Balaram Krishna J Hanumanthu Anika Sasidharan Nair Adarsh Katamreddy Jason S Gilbert Jee Young You Obiageli Lynda Offor Ankit Kushwaha Ankita Krishnan Marzio Napolitano Leonidas Palaidimos Joaquin Morante Seema S. Tekwani Suchita Mehta Aanchal Gupta Harmeen Goraya Mengyang Sun Robert T. Faillace Perminder Gulani |
author_sort |
Balaram Krishna J Hanumanthu |
title |
Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_short |
Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_full |
Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_fullStr |
Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_full_unstemmed |
Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_sort |
sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
publisher |
Korean Society of Critical Care Medicine |
series |
Acute and Critical Care |
issn |
2586-6052 2586-6060 |
publishDate |
2021-08-01 |
description |
Background Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. Methods In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program. Results Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15–18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23–0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24–55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients. Conclusions SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC. |
topic |
cardiomyopathy mortality sepsis septic shock |
url |
http://www.accjournal.org/upload/pdf/acc-2021-00234.pdf |
work_keys_str_mv |
AT balaramkrishnajhanumanthu sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT anikasasidharannair sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT adarshkatamreddy sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT jasonsgilbert sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT jeeyoungyou sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT obiagelilyndaoffor sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT ankitkushwaha sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT ankitakrishnan sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT marzionapolitano sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT leonidaspalaidimos sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT joaquinmorante sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT seemastekwani sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT suchitamehta sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT aanchalgupta sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT harmeengoraya sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT mengyangsun sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT roberttfaillace sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis AT permindergulani sepsisinducedcardiomyopathyisassociatedwithhighermortalityratesinpatientswithsepsis |
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1717761574320472064 |
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doaj-1d064c3eba514e0daea8f481f42a5b012021-09-09T01:09:36ZengKorean Society of Critical Care MedicineAcute and Critical Care2586-60522586-60602021-08-0136321522210.4266/acc.2021.002341306Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsisBalaram Krishna J Hanumanthu0Anika Sasidharan Nair1Adarsh Katamreddy2Jason S Gilbert3Jee Young You4Obiageli Lynda Offor5Ankit Kushwaha6Ankita Krishnan7Marzio Napolitano8Leonidas Palaidimos9Joaquin Morante10Seema S. Tekwani11Suchita Mehta12Aanchal Gupta13Harmeen Goraya14Mengyang Sun15Robert T. Faillace16Perminder Gulani17 Department of Cardiology, Mount Sinai Beth Israel Hospital, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Albert Einstein College of Medicine, Bronx, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Division of Pulmonary and Critical Care Medicine, Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA Institute of Critical Care Medicine, Mount Sinai Hospital, New York, NY, USA Division of Pulmonary and Critical Care Medicine, Beth Israel Lahey Health, Burlington, MA, USA Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Arkansas for Medical Sciences Medical Center, Little Rock, AR, USA Department of Obstetrics and Gynecology, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA Division of Pulmonary and Critical Care Medicine, Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USABackground Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. Methods In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program. Results Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15–18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23–0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24–55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients. Conclusions SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC.http://www.accjournal.org/upload/pdf/acc-2021-00234.pdfcardiomyopathymortalitysepsisseptic shock |