Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection
This work describes a novel and versatile solid-state chemiluminescence sensor for analyte detection using TiO2-Ru(bpy)32+-Ce(IV). Herein, we report the synthesis, characterization, optimization and application of a new type of hybrid nanoparticles (NPs). Mesoporous TiO2-Ru(bpy)32+ NPs were prepared...
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Online Access: | https://doi.org/10.1515/nanoph-2017-0104 |
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doaj-1d1103a7053b4946be58340dccc60b372021-09-06T19:20:31ZengDe GruyterNanophotonics2192-86062192-86142018-02-017368369210.1515/nanoph-2017-0104nanoph-2017-0104Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detectionAl-Hetlani Entesar0Amin Mohamed O.1Madkour Metwally2Chemistry Department, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitChemistry Department, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitChemistry Department, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitThis work describes a novel and versatile solid-state chemiluminescence sensor for analyte detection using TiO2-Ru(bpy)32+-Ce(IV). Herein, we report the synthesis, characterization, optimization and application of a new type of hybrid nanoparticles (NPs). Mesoporous TiO2-Ru(bpy)32+ NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)32+ into the initial reaction mixture at various concentrations. The resultant bright orange precipitate was characterized via transmission electron microscopy, N2 sorpometry, inductively coupled plasma-optical emission spectrometer (ICP-OES), Raman and UV-Vis spectroscopy techniques. The concentration of Ru(bpy)32+ complex in the NPs was quantified using ICP-OES, and its chemiluminescence (CL) response was measured and compared with the same concentration in the liquid phase using oxalate as model analyte. The results showed that this type of hybrid material exhibited a higher CL signal compared with the liquid phase due to the enlarged surface area of the hybrid NPs (~149.6 m2/g). The amount of TiO2-Ru(bpy)32+ NPs and the effect of the analyte flow rate were also investigated to optimize the CL signal. The optimized system was further used to detect oxalate and two pharmaceutical drugs, namely, imipramine and promazine. The linear range for both drugs was 1–100 pm with limits of detection (LOD) of 0.1 and 0.5 pm, respectively. This approach is considered to be simple, low cost and facile and can be applied to a wide range of analytes.https://doi.org/10.1515/nanoph-2017-0104solid-state chemiluminescencenanoparticlesdetectionpharmaceutical drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Al-Hetlani Entesar Amin Mohamed O. Madkour Metwally |
spellingShingle |
Al-Hetlani Entesar Amin Mohamed O. Madkour Metwally Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection Nanophotonics solid-state chemiluminescence nanoparticles detection pharmaceutical drugs |
author_facet |
Al-Hetlani Entesar Amin Mohamed O. Madkour Metwally |
author_sort |
Al-Hetlani Entesar |
title |
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
title_short |
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
title_full |
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
title_fullStr |
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
title_full_unstemmed |
Novel and versatile solid-state chemiluminescence sensor based on TiO2-Ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
title_sort |
novel and versatile solid-state chemiluminescence sensor based on tio2-ru(bpy)32+ nanoparticles for pharmaceutical drugs detection |
publisher |
De Gruyter |
series |
Nanophotonics |
issn |
2192-8606 2192-8614 |
publishDate |
2018-02-01 |
description |
This work describes a novel and versatile solid-state chemiluminescence sensor for analyte detection using TiO2-Ru(bpy)32+-Ce(IV). Herein, we report the synthesis, characterization, optimization and application of a new type of hybrid nanoparticles (NPs). Mesoporous TiO2-Ru(bpy)32+ NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)32+ into the initial reaction mixture at various concentrations. The resultant bright orange precipitate was characterized via transmission electron microscopy, N2 sorpometry, inductively coupled plasma-optical emission spectrometer (ICP-OES), Raman and UV-Vis spectroscopy techniques. The concentration of Ru(bpy)32+ complex in the NPs was quantified using ICP-OES, and its chemiluminescence (CL) response was measured and compared with the same concentration in the liquid phase using oxalate as model analyte. The results showed that this type of hybrid material exhibited a higher CL signal compared with the liquid phase due to the enlarged surface area of the hybrid NPs (~149.6 m2/g). The amount of TiO2-Ru(bpy)32+ NPs and the effect of the analyte flow rate were also investigated to optimize the CL signal. The optimized system was further used to detect oxalate and two pharmaceutical drugs, namely, imipramine and promazine. The linear range for both drugs was 1–100 pm with limits of detection (LOD) of 0.1 and 0.5 pm, respectively. This approach is considered to be simple, low cost and facile and can be applied to a wide range of analytes. |
topic |
solid-state chemiluminescence nanoparticles detection pharmaceutical drugs |
url |
https://doi.org/10.1515/nanoph-2017-0104 |
work_keys_str_mv |
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