| Summary: | Aim: To determine
the most accurate and useful method for calculating creatinine clearance by
comparing the results of different methods. Methods: One hundred type
2 diabetic patients who have been followed by Okmeydani Training and Research
Hospital Internal Medicine and/or diabetes outpatient clinics were included in
this study. Individuals with hypertension, acute kidney disease and renal
transplantation were excluded from the study.Results: Glomerular
filtration rate (GFR) calculated with Cockcroft-Gault formula was significantly
affected by creatinine, weight, and age
(p<0.050 for all). GFR measured with Modification of Diet in Renal Disease (MDRD)
formula was significantly
affected by creatinine and age (p<0.050 for all) in a univariate model; in a
multivariate model, this was significantly
independently affected by creatinine (p=0.001). GFR measured with 24h urine was significantly affected by
creatinine, weight, and age (p<0.050 for
all) in a univariate model; in a multivariate model,
this was significantly
independently affected by weight (p=0.001).
Conclusion: In
this study, those three methods revealed similar results. All of three methods
can be used for evaluating renal functions in Type II diabetic patients but
creatinine clearance with 24 hours urine method requires two patient visits in
a row and a more complex biochemistry laboratory; so in our opinion, this
method may be used as an alternative to the other two methods.
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