Generation of a NONO homozygous knockout human induced pluripotent stem cell line by CRISPR/Cas9 editing
The non-POU domain containing octamer-binding gene (NONO) encodes a member of a small family of RNA-binding and DNA-binding proteins, whose variants can cause intellectual disability and congenital heart defects. In this study, we generated a homozygous NONO knockout (NONO-KO) induced pluripotent st...
Main Authors: | Tong Yi, Rui Bai, Hairui Sun, Feng Lan, Hongjia Zhang, Yihua He |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-08-01
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Series: | Stem Cell Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612030194X |
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