Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran
Background: Phyllodes tumors are uncommon neoplasms of the breast. Data about their outcome is limited. This study aims to evaluate patients diagnosed with phyllodes tumors in terms of local recurrence, distant metastasis and overall survival. Methods: We retrospectively reviewed the medical reco...
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doaj-1d2d2880495f4eb9a74889645da4de152020-11-25T02:08:31ZengShiraz University of Medical SciencesMiddle East Journal of Cancer 2008-67092008-66872015-10-0164267273Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern IranMajid Akrami0Sedigheh Tahmasebi1Abdolrasoul Talei2Ahmad Abdollahi3Sara Hosseini4Masoumeh Namazi5Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgical oncology, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranSouth Fars Cancer Center, Department of Surgical oncology, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: Phyllodes tumors are uncommon neoplasms of the breast. Data about their outcome is limited. This study aims to evaluate patients diagnosed with phyllodes tumors in terms of local recurrence, distant metastasis and overall survival. Methods: We retrospectively reviewed the medical records of 129 women with phyllodes tumors who referred to our center from 1999 to 2013. Clinical and pathological features, local and regional recurrence, distant metastasis and overall survival were determined. SPSS 15.0 statistical software was used for analysis. Results:Mean patient age was 39 years (17-67 years). Mean size of the tumor was 5.38 cm. There were 105 (81.4%) benign, 8 (6.2%) borderline and 16 (12.4%) malignant tumors. The mean follow-up period of patients was 28 months (6 to 128 months). The rate of local recurrence among benign tumors was 3.8% (4 cases); in borderline cases the rate was 12.5% (1 case) and for malignant cases, it was 18.7% (3 cases). Three patients each recurred twice and one patient had local recurrence for a third time. Two patients died of malignant tumor-related disease - one due to advanced regional recurrence and lung metastasis, and the other to wide-spread metastasis. Another patient died from an unrelated cause (myocardial infarction) one year after surgery. For those with malignant phyllodes tumors, the five-year overall survival was 77.8% and disease-free survival rate was 85.7%. Conclusion: Although, the prognosis for phyllodes tumors is good, the malignancy rate is higher in older patients and those with larger tumors. A higher local recurrence rate in malignant phyllodes tumors suggests the importance for adequate resection of margins in surgical management of these tumors.http://mejc.sums.ac.ir/index.php/mejc/article/view/273/230BreastPhyllodes tumorsOutcomeRecurrence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Majid Akrami Sedigheh Tahmasebi Abdolrasoul Talei Ahmad Abdollahi Sara Hosseini Masoumeh Namazi |
spellingShingle |
Majid Akrami Sedigheh Tahmasebi Abdolrasoul Talei Ahmad Abdollahi Sara Hosseini Masoumeh Namazi Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran Middle East Journal of Cancer Breast Phyllodes tumors Outcome Recurrence |
author_facet |
Majid Akrami Sedigheh Tahmasebi Abdolrasoul Talei Ahmad Abdollahi Sara Hosseini Masoumeh Namazi |
author_sort |
Majid Akrami |
title |
Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran |
title_short |
Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran |
title_full |
Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran |
title_fullStr |
Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran |
title_full_unstemmed |
Clinical Outcome of Patients with Breast Phyllodes Tumors: A Retrospective Analysis of 129 Cases in Shiraz, Southern Iran |
title_sort |
clinical outcome of patients with breast phyllodes tumors: a retrospective analysis of 129 cases in shiraz, southern iran |
publisher |
Shiraz University of Medical Sciences |
series |
Middle East Journal of Cancer |
issn |
2008-6709 2008-6687 |
publishDate |
2015-10-01 |
description |
Background: Phyllodes tumors are uncommon neoplasms of the breast. Data
about their outcome is limited. This study aims to evaluate patients diagnosed with
phyllodes tumors in terms of local recurrence, distant metastasis and overall survival.
Methods: We retrospectively reviewed the medical records of 129 women with
phyllodes tumors who referred to our center from 1999 to 2013. Clinical and pathological
features, local and regional recurrence, distant metastasis and overall survival were
determined. SPSS 15.0 statistical software was used for analysis.
Results:Mean patient age was 39 years (17-67 years). Mean size of the tumor was
5.38 cm. There were 105 (81.4%) benign, 8 (6.2%) borderline and 16 (12.4%)
malignant tumors. The mean follow-up period of patients was 28 months (6 to 128
months). The rate of local recurrence among benign tumors was 3.8% (4 cases); in
borderline cases the rate was 12.5% (1 case) and for malignant cases, it was 18.7% (3
cases). Three patients each recurred twice and one patient had local recurrence for a
third time. Two patients died of malignant tumor-related disease - one due to advanced
regional recurrence and lung metastasis, and the other to wide-spread metastasis.
Another patient died from an unrelated cause (myocardial infarction) one year after
surgery. For those with malignant phyllodes tumors, the five-year overall survival was
77.8% and disease-free survival rate was 85.7%.
Conclusion: Although, the prognosis for phyllodes tumors is good, the malignancy
rate is higher in older patients and those with larger tumors. A higher local recurrence
rate in malignant phyllodes tumors suggests the importance for adequate resection of
margins in surgical management of these tumors. |
topic |
Breast Phyllodes tumors Outcome Recurrence |
url |
http://mejc.sums.ac.ir/index.php/mejc/article/view/273/230 |
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