Androgens inhibit androgen receptor promoter activation in motor neurons

Androgens inhibit androgen receptor promoter activation in motor neurons

The androgen receptor (AR), a ligand-activated transcription factor, has been found mutated in several human diseases. While some mutations reduce, others potentiate AR functions generating different endocrine dysfunctions. A peculiar AR mutation, the CAG-repeat expansion encoding the AR-polyglutami...

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Bibliographic Details
Main Authors: Guglielmo Vismara, Francesca Simonini, Elisa Onesto, Marta Bignamini, Veronica Miceli, Luciano Martini, Angelo Poletti
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Neurobiology of Disease
Subjects:
Androgen receptor
Spinal and bulbar muscular atrophy
Kennedy's disease
Polyglutamine disease
Motor neuron
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002829

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108002829

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