Esterase mutation is a mechanism of resistance to antimalarial compounds
Pepstatin is a known inhibitor of malarial proteases, but its activity varies between sources. Here, Istvanet al. identify a pepstatin ester as the active component of pepstatin preparations and show that this prodrug is activated by a Plasmodiumesterase, mutation of which can confer resistance to p...
Main Authors: | Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14240 |
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