Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.

Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.

Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytosp...

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Main Authors: Chengwen Wei, Qin Deng, Mengyu Sun, Jing Xu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
<i>Cytospora</i> sp.
polyketides
structure identification
antimicrobial activity
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/25/18/4224
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spelling doaj-1d467807b18148de891e44bfaad1bcbc2020-11-25T03:41:20ZengMDPI AGMolecules1420-30492020-09-01254224422410.3390/molecules25184224Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. Chengwen Wei0Qin Deng1Mengyu Sun2Jing Xu3Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaCollege of Horticulture and Landscape, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaTwo new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ±  0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM).https://www.mdpi.com/1420-3049/25/18/4224<i>Cytospora</i> sp.polyketidesstructure identificationantimicrobial activitycytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
spellingShingle Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
Molecules
<i>Cytospora</i> sp.
polyketides
structure identification
antimicrobial activity
cytotoxicity
author_facet Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
author_sort Chengwen Wei
title Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_short Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_full Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_fullStr Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_full_unstemmed Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_sort cytospyrone and cytospomarin: two new polyketides isolated from mangrove endophytic fungus, <i>cytospora</i> sp.
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-09-01
description Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ±  0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM).
topic <i>Cytospora</i> sp.
polyketides
structure identification
antimicrobial activity
cytotoxicity
url https://www.mdpi.com/1420-3049/25/18/4224
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