Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis
Background: Rheumatoid arthritis (RA) is a disease involving various types of cytokines. One of them is interleukin-17 (IL-17), which is known to have a pleiotropic effect on various of cells and is thought to be a cytokine effector contributing to the pathogenic condition in RA. Methods: The study...
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doaj-1d4929863e8b4bbc98afeb9dc633a7972021-02-16T14:23:20ZengIndonesia Rheumatology AssociationIndonesian Journal of Rheumatology2086-14352581-11422018-02-012210.37275/ijr.v2i3.8080Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritisJeffrey Arthur Ongkowijaya0Bambang Setiyohadi1Ida Ayu Ratih Wulansari Manuaba2Yoga I Kasjmir3Division of Rheumatology, Department of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, JakartaDivision of Rheumatology, Department of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, JakartaDepartment of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, JakartaDivision of Rheumatology, Department of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, JakartaBackground: Rheumatoid arthritis (RA) is a disease involving various types of cytokines. One of them is interleukin-17 (IL-17), which is known to have a pleiotropic effect on various of cells and is thought to be a cytokine effector contributing to the pathogenic condition in RA. Methods: The study was conducted on 46 RA patients at rheumatology clinic at the Cipto Mangunkusumo General Hospital who were diagnosed based on the 1987 American College of Rheumatology criteria. Sample selection was done using consecutive sampling. Tests on patients were conducted to collect data needed to obtain the scores for 28-joint Disease Activity Score (DAS28), global health visual analogue scale, swollen joint count, tender joint count, sedimentation rate, Sharp score (radiograph of both hands), and the IL-17 level. The correlation between IL-17 level and DAS28 was calculated using the Pearson’s correlation test while the correlation between IL-17 level and Sharp score was calculated using the Spearman’s test. Results: The majority of patients (87%) were women. The largest percentage was in the 51- to 60-year-old group (39.1%). Most patients (43.1%) had moderate disease activity. There were 27 patients (58.69%) with positive rheumatoid factor. The mean IL-17 level was 17.28 pg/mL with a standard deviation of 11.43 pg/mL. There was no correlation of IL-17 level with disease activity (p = 0.446, r = 0.021) and Sharp score (p = 0.304, r = 0.077) in subjects of this study. Conclusion: There was no signifi cant correlation of IL-17 with disease activity and joint damage.https://journalrheumatology.or.id/index.php/ijr/article/view/80 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeffrey Arthur Ongkowijaya Bambang Setiyohadi Ida Ayu Ratih Wulansari Manuaba Yoga I Kasjmir |
spellingShingle |
Jeffrey Arthur Ongkowijaya Bambang Setiyohadi Ida Ayu Ratih Wulansari Manuaba Yoga I Kasjmir Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis Indonesian Journal of Rheumatology |
author_facet |
Jeffrey Arthur Ongkowijaya Bambang Setiyohadi Ida Ayu Ratih Wulansari Manuaba Yoga I Kasjmir |
author_sort |
Jeffrey Arthur Ongkowijaya |
title |
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
title_short |
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
title_full |
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
title_fullStr |
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
title_full_unstemmed |
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
title_sort |
correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis |
publisher |
Indonesia Rheumatology Association |
series |
Indonesian Journal of Rheumatology |
issn |
2086-1435 2581-1142 |
publishDate |
2018-02-01 |
description |
Background: Rheumatoid arthritis (RA) is a disease involving various types of cytokines. One of them is interleukin-17 (IL-17), which is known to have a pleiotropic effect on various of cells and is thought to be a cytokine effector contributing to the pathogenic
condition in RA.
Methods: The study was conducted on 46 RA patients at rheumatology clinic at the Cipto Mangunkusumo General Hospital who were diagnosed based on the 1987 American College of Rheumatology criteria. Sample selection was done using consecutive sampling. Tests on patients were conducted to collect data needed to obtain the scores for 28-joint Disease Activity Score (DAS28), global health visual analogue scale, swollen joint count, tender joint count, sedimentation rate, Sharp score (radiograph of both hands), and the IL-17 level.
The correlation between IL-17 level and DAS28 was calculated using the Pearson’s correlation test while the correlation between IL-17 level and Sharp score was calculated using the Spearman’s test.
Results: The majority of patients (87%) were women. The largest percentage was in the 51- to 60-year-old group (39.1%). Most patients (43.1%) had moderate disease activity. There were 27 patients (58.69%) with positive rheumatoid factor. The mean IL-17 level was
17.28 pg/mL with a standard deviation of 11.43 pg/mL. There was no correlation of IL-17 level with disease activity (p = 0.446, r = 0.021) and Sharp score (p = 0.304, r = 0.077) in subjects of this study.
Conclusion: There was no signifi cant correlation of IL-17 with disease activity and joint damage. |
url |
https://journalrheumatology.or.id/index.php/ijr/article/view/80 |
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